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Serendipitous late-stage modification of dipeptide by using AIBN and thioacetic acid

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Field Value
 
Title Serendipitous late-stage modification of dipeptide by using AIBN and thioacetic acid
 
Creator Kotha, Sambasivarao
Gupta, Naveen Kumar
Ansari, Saima
 
Subject Peptide modification
Azodiisobutyronitrile (AIBN)
Thiophene
Serendipity
Propargyl group
 
Description 513-517
Post-assembly peptide modifications have become an integral part of medicinal chemistry nowadays. This exercise is
useful in finding novel bioconjugates, therapeutic peptides and protein labelling. Therefore, in our attempts towards the
modification of peptides, we have tried to insert thiophene moiety in dipropargyl dipeptide in the presence of AIBN and
thioacetic acid. Surprisingly, instead of thiophene group introduction, we observe the serendipitous functionalization of
amide group i.e. –NHCOCH3 is converted into –NHCHO group.
 
Date 2023-05-18T05:14:42Z
2023-05-18T05:14:42Z
2023-05
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61923
https://doi.org/10.56042/ijc.v62i5.1431
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(05) [May 2023]