Serendipitous late-stage modification of dipeptide by using AIBN and thioacetic acid
NOPR - NISCAIR Online Periodicals Repository
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Title |
Serendipitous late-stage modification of dipeptide by using AIBN and thioacetic acid
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Creator |
Kotha, Sambasivarao
Gupta, Naveen Kumar Ansari, Saima |
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Subject |
Peptide modification
Azodiisobutyronitrile (AIBN) Thiophene Serendipity Propargyl group |
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Description |
513-517
Post-assembly peptide modifications have become an integral part of medicinal chemistry nowadays. This exercise is useful in finding novel bioconjugates, therapeutic peptides and protein labelling. Therefore, in our attempts towards the modification of peptides, we have tried to insert thiophene moiety in dipropargyl dipeptide in the presence of AIBN and thioacetic acid. Surprisingly, instead of thiophene group introduction, we observe the serendipitous functionalization of amide group i.e. –NHCOCH3 is converted into –NHCHO group. |
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Date |
2023-05-18T05:14:42Z
2023-05-18T05:14:42Z 2023-05 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61923 https://doi.org/10.56042/ijc.v62i5.1431 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(05) [May 2023]
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