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Design and synthesis of phosphonate functionalized naphthalenediimide: Application to induce mitochondria mediated apoptosis in the human skin melanoma cells (SKMEL2)

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Title Design and synthesis of phosphonate functionalized naphthalenediimide: Application to induce mitochondria mediated apoptosis in the human skin melanoma cells (SKMEL2)
 
Creator Kharat, Kiran R
Bhosale, Rajesh S
Nandre, Kamalakar P
Biradar, Madan R
Bhosale, Sheshanath V
Bhosale, Sidhanath V
 
Subject Phosphonate
Naphthalenediimide
Mitochondria
Apoptosis
SKMEL2
 
Description 506-512
New phosphonate functionalized naphthalenediimides (NDI-1 and NDI-2) have been synthesized and evaluated as
potential drug candidates to treat the skin malignancy. The aforementioned candidates have resulted in an induced apoptosis
pathway of cytotoxicity, at concentrations lower than 4 μM, in human skin melanoma cells, and elicited a stronger apoptotic
response in cells. Regulation of the Bcl2, Caspases, Bak1, Bax protein in NDI-induced apoptosis in cells has been analyzed
by real time PCR, and the cell viability and apoptosis determined by flow cytometry. The obtained results indicate that NDIinduced
apoptosis by regulation of Bcl2 and Bak1 occurs in human skin melanoma cells (SKMEL-2).
 
Date 2023-05-18T05:17:25Z
2023-05-18T05:17:25Z
2023-05
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61924
https://doi.org/10.56042/ijc.v62i5.1430
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(05) [May 2023]