Investigation of chalcone cyclized pyrazole derivatives as an anti-inflammatory agent: In-vivo and in-silico molecular docking approach
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Title |
Investigation of chalcone cyclized pyrazole derivatives as an anti-inflammatory agent: In-vivo and in-silico molecular docking approach
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Creator |
Jain, Naman
Abdu, Raihan Tambekar, Omkar Bedse, Mayuri Goel, Tanvi Dev, Sanal Bansode, Deepali |
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Subject |
Pyrazole
Pyrazoline Chalcone Anti-inflammatory In-vivo In-silico drug design |
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Description |
465-471
A novel pyrazole condensed with chalcone and pyrazoline derivatives have been synthesized and evaluated against antiinflammatory activity using a standard method of acute carrageenan-induced rat paw edema in vivo. NJD1 would be the most potent compound (30.10 ± 0.02%) found to be inhibitory in rats and exhibiting activity similar to celecoxib as a reference standard. Molecular docking studies have been conducted on PDB: 1TD7, the 3D X-ray crystallographic structure of group I protein phospholipase A2 (PLA2), -5.609 kcal/mol is the binding affinity of the standard celecoxib. The synthesized derivatives NJD1 and NJD2 (-6.283, -6.057 kcal/mol) has exhibited greater binding affinity, respectively. |
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Date |
2023-05-18T05:24:40Z
2023-05-18T05:24:40Z 2023-05 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61927 https://doi.org/10.56042/ijc.v62i5.1437 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(05) [May 2023]
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