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Investigation of chalcone cyclized pyrazole derivatives as an anti-inflammatory agent: In-vivo and in-silico molecular docking approach

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Title Investigation of chalcone cyclized pyrazole derivatives as an anti-inflammatory agent: In-vivo and in-silico molecular docking approach
 
Creator Jain, Naman
Abdu, Raihan
Tambekar, Omkar
Bedse, Mayuri
Goel, Tanvi
Dev, Sanal
Bansode, Deepali
 
Subject Pyrazole
Pyrazoline
Chalcone
Anti-inflammatory
In-vivo
In-silico drug design
 
Description 465-471
A novel pyrazole condensed with chalcone and pyrazoline derivatives have been synthesized and evaluated against antiinflammatory
activity using a standard method of acute carrageenan-induced rat paw edema in vivo. NJD1 would be the
most potent compound (30.10 ± 0.02%) found to be inhibitory in rats and exhibiting activity similar to celecoxib as a
reference standard. Molecular docking studies have been conducted on PDB: 1TD7, the 3D X-ray crystallographic structure
of group I protein phospholipase A2 (PLA2), -5.609 kcal/mol is the binding affinity of the standard celecoxib. The
synthesized derivatives NJD1 and NJD2 (-6.283, -6.057 kcal/mol) has exhibited greater binding affinity, respectively.
 
Date 2023-05-18T05:24:40Z
2023-05-18T05:24:40Z
2023-05
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61927
https://doi.org/10.56042/ijc.v62i5.1437
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(05) [May 2023]