Synthesis of 1,2,4-oxadiazoles utilizing ethyl 2-cyano-2-(2- nitrophenylsulfonyloxyimino) acetate (ortho-nosylOXY) as a catalyst and dehydrating reagent under microwave irradiation
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Title |
Synthesis of 1,2,4-oxadiazoles utilizing ethyl 2-cyano-2-(2- nitrophenylsulfonyloxyimino) acetate (ortho-nosylOXY) as a catalyst and dehydrating reagent under microwave irradiation
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Creator |
Chandra, Jyoti
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Subject |
1,2,4-Oxadiazoles
ortho-NosylOXY O-Acylation Cyclization Environment friendly |
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Description |
454-464
The present work describes the development of an optimized microwave-assisted synthesis of 1,2,4-oxadiazoles from carboxylic acids and amidoximes using ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino) acetate (ortho-NosylOXY) as an activating agent of carboxylic acid for O-acylation step followed by cyclization step in one pot with significantly good yield. Interestingly, the same reagent, ortho-NosylOXY, acts as a catalyst for the first step and helps as a dehydrating agent for the second step. Moreover, by-products, Oxyma [ethyl 2-cyano-2-(hydroxyimino) acetate] and 2-nitrobenzenesulfonic acid can easily be recovered back and recycled further to prepare the reagent. This method is environment friendly and cost-effective. |
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Date |
2023-05-18T05:26:40Z
2023-05-18T05:26:40Z 2023-05 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61928 https://doi.org/10.56042/ijc.v62i5.1428 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(05) [May 2023]
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