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In silico functional elucidation of uncharacterized proteins of Chlamydia abortus strain LLG.

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Title In silico functional elucidation of uncharacterized proteins of Chlamydia abortus strain LLG.
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Creator Singh G, Sharma D, Singh V, Rani J, Marotta F, Kumar M, Mal G, Singh B.
 
Subject Chlamydia abortus • functional annotation • hypothetical proteins
 
Description Not Available
Aim: This study reports structural modeling, molecular dynamics profiling of hypothetical
proteins in Chlamydia abortus genome database. Methodology: The hypothetical
protein sequences were extracted from C. abortus LLG Genome Database for functional
elucidation using in silico methods. Results: Fifty-one proteins with their roles in defense,
binding and transporting other biomolecules were unraveled. Forty-five proteins were
found to be nonhomologous to proteins present in hosts infected by C. abortus. Of
these, 31 proteins were related to virulence. The structural modeling of two proteins,
first, WP_006344020.1 (phosphorylase) and second, WP_006344325.1 (chlamydial
protease/proteasome-like activity factor) were accomplished. The conserved active sites
necessary for the catalytic function were analyzed. Conclusion: The finally concluded
proteins are envisioned as possible targets for developing drugs to curtail chlamydial
infections, however, and should be validated by molecular biological methods
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Date 2023-05-25T04:45:40Z
2023-05-25T04:45:40Z
2017-01-01
 
Type Review Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/77743
 
Language English
 
Relation Not Available;
 
Publisher Not Available