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Isolation and propagation of neural stem cells in caprine (Capra hircus).

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Title Isolation and propagation of neural stem cells in caprine (Capra hircus).
Not Available
 
Creator Pranjali Agarwal
Manish Kumar
Kuldeep Kumar
Renu Singh
PS Mahapatra
Ajay Kumar
SK Bhure
Dhruba Malakar
Mihir Sarkar
Sadhan Bag
 
Subject NSC
characterisation
differentiation
goat/caprine
isolation
 
Description Not Available
Neural stem cells (NSCs) can self-renew and give rise to neurons, astrocytes and oligodendrocytes; they are found in the nervous system of mammalian organisms, representing a promising resource for both fundamental research and therapeutics. There have been few investigations on NSCs in the livestock species. Therefore, we have successfully isolated and characterised NSCs from the foetal brain of a small domestic animal, the goat (called GNSCs). These cells from the foetal brain showed self-renewal, rapid proliferation with a population doubling time of 88 h, were morphologically homogeneous and maintained normal chromosome throughout the culture period. The cells expressed NSC-specific markers (Sox2, Pax6 and Mushashi), but were negative for CD34 and CD45. They were capable of multi-differentiation into neurons, astrocytes, oligodendrocytes, as well as adipocytes and osteocytes. The availability of such cells may hold great interest for basic and applied neuroscience.
Not Available
 
Date 2023-05-30T08:44:54Z
2023-05-30T08:44:54Z
2014-04-08
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/77894
 
Language English
 
Relation Not Available;
 
Publisher Wiley