Isolation and propagation of neural stem cells in caprine (Capra hircus).
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Title |
Isolation and propagation of neural stem cells in caprine (Capra hircus).
Not Available |
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Creator |
Pranjali Agarwal
Manish Kumar Kuldeep Kumar Renu Singh PS Mahapatra Ajay Kumar SK Bhure Dhruba Malakar Mihir Sarkar Sadhan Bag |
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Subject |
NSC
characterisation differentiation goat/caprine isolation |
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Description |
Not Available
Neural stem cells (NSCs) can self-renew and give rise to neurons, astrocytes and oligodendrocytes; they are found in the nervous system of mammalian organisms, representing a promising resource for both fundamental research and therapeutics. There have been few investigations on NSCs in the livestock species. Therefore, we have successfully isolated and characterised NSCs from the foetal brain of a small domestic animal, the goat (called GNSCs). These cells from the foetal brain showed self-renewal, rapid proliferation with a population doubling time of 88 h, were morphologically homogeneous and maintained normal chromosome throughout the culture period. The cells expressed NSC-specific markers (Sox2, Pax6 and Mushashi), but were negative for CD34 and CD45. They were capable of multi-differentiation into neurons, astrocytes, oligodendrocytes, as well as adipocytes and osteocytes. The availability of such cells may hold great interest for basic and applied neuroscience. Not Available |
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Date |
2023-05-30T08:44:54Z
2023-05-30T08:44:54Z 2014-04-08 |
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Type |
Research Paper
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Identifier |
Not Available
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/77894 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Wiley
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