Immunoprotection in mice immunized with native OmpH, recombinant OmpH and HS alum precipitated vaccine of Pasteurella multocida P52 against P. multocida challenge
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Title |
Immunoprotection in mice immunized with native OmpH, recombinant OmpH and HS alum precipitated vaccine of Pasteurella multocida P52 against P. multocida challenge
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Creator |
Jogi, Joycee
Nayak, Anju Rai, Ajay Dubey, Amita |
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Subject |
Buffaloes
Cattle Hemorrhagic septicemia Indirect ELISA Outer membrane proteins Poultry |
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Description |
436-441
Outer membrane proteins (OMPs) of Pasteurella multocida play an important role in virulence and are important for vaccine development due to immunogenicity. Here, we evaluated immunoprotection in mice, immunized with native OmpH, recombinant OmpH and HS alum precipitated vaccine of P. multocida P52 against P. multocida challenge. Protection studies were performed in mice of groups I (OmpH); II (recombinant OmpH); and III (HS alum precipitated vaccine). Group IV was control group administered with sterile PBS. The protection percentage was recorded as 83.33% protection in Gr. I & III, and 66.66% in Gr. II. The control group (Gr. IV) showed 100% mortality. The mean antibodies titers were detected at day 7, 14, 21 and 28 postimmunization, and compared with the control group. All immunized groups showed significantly high immune protection compared to the control group. |
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Date |
2023-06-02T05:19:10Z
2023-06-02T05:19:10Z 2023-06 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61979 https://doi.org/10.56042/ijeb.v61i06.1941 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJEB Vol.61(06) [June 2023]
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