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Immunoprotection in mice immunized with native OmpH, recombinant OmpH and HS alum precipitated vaccine of Pasteurella multocida P52 against P. multocida challenge

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Title Immunoprotection in mice immunized with native OmpH, recombinant OmpH and HS alum precipitated vaccine of Pasteurella multocida P52 against P. multocida challenge
 
Creator Jogi, Joycee
Nayak, Anju
Rai, Ajay
Dubey, Amita
 
Subject Buffaloes
Cattle
Hemorrhagic septicemia
Indirect ELISA
Outer membrane proteins
Poultry
 
Description 436-441
Outer membrane proteins (OMPs) of Pasteurella multocida play an important role in virulence and are important for vaccine development due to immunogenicity. Here, we evaluated immunoprotection in mice, immunized with native OmpH, recombinant OmpH and HS alum precipitated vaccine of P. multocida P52 against P. multocida challenge. Protection studies were performed in mice of groups I (OmpH); II (recombinant OmpH); and III (HS alum precipitated vaccine). Group IV was control group administered with sterile PBS. The protection percentage was recorded as 83.33% protection in Gr. I & III, and 66.66% in Gr. II. The control group (Gr. IV) showed 100% mortality. The mean antibodies titers were detected at day 7, 14, 21 and 28 postimmunization, and compared with the control group. All immunized groups showed significantly high immune protection compared to the control group.
 
Date 2023-06-02T05:19:10Z
2023-06-02T05:19:10Z
2023-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61979
https://doi.org/10.56042/ijeb.v61i06.1941
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(06) [June 2023]