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A topical formulation of Anacardium occidentale L. leaves extract enhances wound healing via mediating TNF-α and TGF- β

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Title A topical formulation of Anacardium occidentale L. leaves extract enhances wound healing via mediating TNF-α and TGF- β
 
Creator Nehete, Minakshi
De, Suparna
Degani, Mariam
Tatke, Pratima
 
Subject Cashew tree
Glycogen synthase kinase-3β protein (GSK3-β)
Growth factor
In silico molecular docking
Kaju
Pro-inflammatory cytokine
Wnt signaling pathway
 
Description 424-435
Repeated trauma, inadequate perfusion or oxygenation, excessive inflammation, infection, oxidative stress, and
diabetes all contribute to impaired wound healing. In a clinical setting, delay in healing may result in severe complications
such as gangrene, leading to extended hospitalization, amputation and even death of the patient. Slow wound healing and
limitations of currently available synthetic medication, urges the need for a safe, affordable, patient-friendly, and
multi-modal herbal wound care agent. Anacardium occidentale L., commonly known as cashew and locally, Kaju, is
reported to possess antidiabetic, antibacterial, antioxidant, anti-inflammatory and antiulcerogenic activities. In this study, we
evaluated the wound healing activity of gel containing the extract of A. occidentale leaves in rats using incision, excision
and dead space wound models. Increased wound contraction, breaking strength, hydroxyproline and hexosamine content,
TGF-β level and decreased level of TNF-α indicated that the developed gel accelerated the wound healing process.
Moreover, the docking studies indicated that the aqueous alcoholic extract exerted healing activity by inhibiting GSK3-β
through β-catenin dependent Wnt signaling pathway. Thus, it can be concluded that the Anacardium occidentale leaves
extract can be a potential wound healing agent by acting on various phases of healing process.
 
Date 2023-06-02T05:34:55Z
2023-06-02T05:34:55Z
2023-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61980
https://doi.org/10.56042/ijeb.v61i06.1926
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(06) [June 2023]