Record Details

Protective effects of ursolic acid on cyclophosphamide induced hemorrhagic cystitis in rats

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Protective effects of ursolic acid on cyclophosphamide induced hemorrhagic cystitis in rats
 
Creator S, Sevimli
Y, Sunucu Karafakıoğlu
M, Düz
 
Subject Antineoplastic
Cancer chemotherapy
Mesna
Plantain
White man’s foot
 
Description 409-416
Cyclophosphamide (CP) is a commonly used antineoplastic agent despite its adverse effects. Hemorrhagic cystitis (HC)
is one of the most common side effects of CP. Although Mesna is commonly used to prevent HC, it suffers from few side
effects. Therefore, search for better alternate substance still continues. In this study, we studied the effects of ursolic acid
(UA), one of the active ingredients of Plantago major, commonly called plantain or white man’s foot, in CP-induced
hemorrhagic cystitis in rats. Forty-nine Sprague−Dawley rats in seven equal groups viz. control (C); cyclophosphamide
(CP); cyclophosphamide+Mesna (CPMesna); cyclophosphamide+ursolic acid [100 (CPUA100) and 200 mg (CPUA200)],
and cyclophosphamide+ mesna+ ursolic acid (100, (CPMesnaUA100) and (200 mg (CPMesnaUA200) were investigated for
inducible nitric oxide synthetase (iNOs), total antioxidant status (TAS), total antioxidant status (TOS), TNF–α, interleukin
10 (IL–10) and interleukin 6 (IL–6) levels from blood samples. The data obtained were statistically analyzed using SPSS
and both Kruskall Wallis and Dunn tests were performed. Value of P
 
Date 2023-06-02T05:43:14Z
2023-06-02T05:43:14Z
2023-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61982
https://doi.org/
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(06) [June 2023]