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Host factors subverted by Mycobacterium tuberculosis: Potential targets for host directed therapy

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Host factors subverted by Mycobacterium tuberculosis: Potential targets for host directed therapy
 
Creator Kalra, Rashi
Tiwari, Drishti
Dkhar, H Kitdorlang
Bhagyaraj, Ella
Kumar, Rajesh
Bhardwaj, Anshu
Gupta, Pawan
 
Subject QR Microbiology
 
Description ntroduction: Despite new approaches in the diagnosis and treatment of tuberculosis (TB), it continues to be a major health burden. Several immunotherapies that potentiate the immune response have come up as adjuncts to drug therapies against drug resistant TB strains; however, there needs to be an urgent appraisal of host specific drug targets for improving their clinical management and to curtail disease progression. Presently, various host directed therapies (HDTs) exist (repurposed drugs, nutraceuticals, monoclonal antibodies and immunomodulatory agents), but these mostly address molecules that combat disease progression.

Areas covered: The current review discusses major Mycobacterium tuberculosis (M. tuberculosis) survival paradigms inside the host and presents a plethora of host targets subverted by M. tuberculosis which can be further explored for future HDTs. The host factors unique to M. tuberculosis infection (in humans) have also been identified through an in-silico interaction mapping.

Expert opinion: HDTs could become the next-generation adjunct therapies in order to counter antimicrobial resistance and virulence, as well as to reduce the duration of existing TB treatments. However, current scientific efforts are largely directed toward combatants rather than host molecules co-opted by M. tuberculosis for its survival. This might drive the immune system to a hyper-inflammatory condition; therefore, we emphasize that host factors subverted by M. tuberculosis, and their subsequent neutralization, must be considered for development of better HDTs.
 
Publisher Taylor and Francis Online
 
Date 2023
 
Type Article
PeerReviewed
 
Relation https://www.tandfonline.com/doi/abs/10.1080/08830185.2021.1990277?journalCode=iiri20
http://crdd.osdd.net/open/3087/
 
Identifier Kalra, Rashi and Tiwari, Drishti and Dkhar, H Kitdorlang and Bhagyaraj, Ella and Kumar, Rajesh and Bhardwaj, Anshu and Gupta, Pawan (2023) Host factors subverted by Mycobacterium tuberculosis: Potential targets for host directed therapy. International reviews of immunology, 42 (1). pp. 43-70.