Record Details

Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis
 
Creator Kumar, Reetesh
Srivastava, Yogesh
Muthuramalingam, Pandiyan
Singh, Kumar Sunil
Verma, Geetika
Tiwari, Savitri
Tandel, Nikunj
Beura, Kumar Samir
Panigrahi, Ramachandra Abhishek
Maji, Somnath
Sharma, Prakriti
Rai, Kumar Pankaj
Prajapati , Kumar Dinesh
Shin , Hyunsuk
Tyagi, Rajeev K
 
Subject QR Microbiology
 
Description Genetic variant(s) of concern (VoC) of SARS-CoV-2 have been emerging worldwide due to mutations in the gene encoding spike glycoprotein. We performed comprehensive analyses of spike protein mutations in the significant variant clade of SARS-CoV-2, using the data available on the Nextstrain server. We selected various mutations, namely, A222V, N439K, N501Y, L452R, Y453F, E484K, K417N, T478K, L981F, L212I, N856K, T547K, G496S, and Y369C for this study. These mutations were chosen based on their global entropic score, emergence, spread, transmission, and their location in the spike receptor binding domain (RBD). The relative abundance of these mutations was mapped with global mutation D614G as a reference. Our analyses suggest the rapid emergence of newer global mutations alongside D614G, as reported during the recent waves of COVID-19 in various parts of the world. These mutations could be instrumentally imperative for the transmission, infectivity, virulence, and host immune system's evasion of SARS-CoV-2. The probable impact of these mutations on vaccine effectiveness, antigenic diversity, antibody interactions, protein stability, RBD flexibility, and accessibility to human cell receptor ACE2 was studied in silico. Overall, the present study can help researchers to design the next generation of vaccines and biotherapeutics to combat COVID-19 infection.
 
Publisher MDPI
 
Date 2023-03-27
 
Type Article
PeerReviewed
 
Relation https://doi.org/10.3390/v15040856
http://crdd.osdd.net/open/3091/
 
Identifier Kumar, Reetesh and Srivastava, Yogesh and Muthuramalingam, Pandiyan and Singh, Kumar Sunil and Verma, Geetika and Tiwari, Savitri and Tandel, Nikunj and Beura, Kumar Samir and Panigrahi, Ramachandra Abhishek and Maji, Somnath and Sharma, Prakriti and Rai, Kumar Pankaj and Prajapati , Kumar Dinesh and Shin , Hyunsuk and Tyagi, Rajeev K (2023) Understanding Mutations in Human SARS-CoV-2 Spike Glycoprotein: A Systematic Review & Meta-Analysis. Viruses Basel , 15 (4).