Record Details

The cytotoxic activity of Sponges and Tunicates from Turkish Aegean Sea

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title The cytotoxic activity of Sponges and Tunicates from Turkish Aegean Sea
 
Creator Uras, İ S
Mutlu, B
Koç, R Ç
Konuklugil, B
 
Subject Anti-cancer activity
Cytotoxic activity
Marine natural products
Sea sponge
Tunicate
 
Description 745-752
The enormous bioactive components of different species from marine habitats make them attractive candidates for the
discovery of new therapeutic active substances in several diseases such as cancer. Sea sponge and tunicate materials are the
ideal sources of new chemotherapeutics for various cancers due to their rich metabolites. The fundamental purpose of the
current study is to investigate the cytotoxic activity of methanolic crude extracts of sponges (Agelas oroides and Cladocora
caespitosa) and tunicates (Ascidiella aspersa and Styela clava) collected from the Aegean Sea. The cytotoxic activity and
the anti-cancer activity of the extracts was carried out by sodium 3´- [1- (diphenyl aminocarbonyl)-3,4-tetrazolium] -bis (4-
methoxy 6-nitro) benzene sulfonic acid hydrate (XTT) on gastric adenocarcinoma cell line AGS, prostate cancer cell line
PC-3, neuroblastoma cell line SH-SY5Y, and mouse fibroblast cell line L929. The extracts of sponge and tunicate were
found to cause different cytotoxic effects on different cancer cells, largely in a concentration-dependent manner. It is found
that the extracts exhibited high anti-cancer activities in neuroblastoma and prostate cancer cell lines at concentrations of 3
and 5 mg/ml. No significant cytotoxic activity was found in L929 cells. In addition, the microscopic examination of cells
treated with the extracts shows that the extracts cause morphological changes with cellular rounding, which could be
associated with apoptosis.
 
Date 2023-06-07T09:32:00Z
2023-06-07T09:32:00Z
2023-06
 
Type Article
 
Identifier 2582-6727 (Online); 2582-6506 (Print)
http://nopr.niscpr.res.in/handle/123456789/62022
https://doi.org/10.56042/ijms.v51i09.2335
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJMS Vol.51(09) [September 2022]