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Synthesis of alkaloids 3,3’-(pyridin-2-yl)methylene)bis(1H-sustituted-indole) via infra red irradiation as heating and their evaluation antifungal against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus

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Title Synthesis of alkaloids 3,3’-(pyridin-2-yl)methylene)bis(1H-sustituted-indole) via infra red irradiation as heating and their evaluation antifungal against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus
 
Creator Rojas-Jaramillo, José Abraham
Penieres-Carrillo, José Guillermo
Sánchez, Tonatiuh Alejandro Cruz
Reyes-Márquez, Viviana
Morales-Morales, David
Pérez-Flores, Francisco
Cosio-Castañeda, Carlos
Morales-Salaza, Ivette
Luna-Mora, Ricardo-Alfredo
 
Subject 3,3’-(Pyridin-2-yl)methylene)bis(1H-sustituted-indole)
Infra red irradiation
Antifungal activity
Candida albicans
Cryptococcus neoformans
Aspergillus fumigatus
 
Description 634-643
Herein is reported a comparative study of a series of new alkaloids structurally related to turbomycin, namely 3,3'-
(pyridin-2-yl)methylene)bis(1H-indole) 15, 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) 16, 3,3’-(pyridin-2-
yl)methylene)bis(2-methyl-1H-indole) 17 and 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) 18, compounds that
have been synthesized through infra red irradiation as an efficient green activation process. In addition, these
diindolylmethanes have been evaluated against levaduriform fungi (Candida albicans (ATCC 10231) and Cryptococcus
neoformans (ATCC 36556)) and filamentous fungi (Aspergillus fumigatus (ATCC 13073)), with the 3,3’-(pyridin-2-yl)
methylene)bis(2-phenyl-1H-indole) 15 derivative being the one exhibiting the best activity of the series. The derivatives 15-
18 exhibit a Minimum Inhibitory Concentrations (MIC) > 900 for C. albicans and C. neoformans ≤ 600.
 
Date 2023-06-15T06:28:51Z
2023-06-15T06:28:51Z
2023-06
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62030
https://doi.org/10.56042/ijc.v62i6.2533
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(06) [June 2023]