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Microwave-assisted synthesis of -CF3 functionalized 3,4-dihydropyrimidinone/thione/imine derivatives by using potassium phthalimide (PPI) as a green and reusable organocatalyst and their anti-microbial evaluation

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Title Microwave-assisted synthesis of -CF3 functionalized 3,4-dihydropyrimidinone/thione/imine derivatives by using potassium phthalimide (PPI) as a green and reusable organocatalyst and their anti-microbial evaluation
 
Creator Odiya, Suresh P
Das, Siva Prasad
Boruah, Jeena Jyoti
 
Subject Biginelli reaction
-CF3 functional group
3,4-Dihydropyrimidinone/thione/imine derivatives
Potassium phthalimide (PPI)
One-pot synthesis
Microwave irradiation
Solvent-free
Anti-microbial activity
 
Description 600-617
One-pot synthesis of novel -CF3 functional group containing 3,4-dihydropyrimidinone/thione/imine derivatives 8a-l, 9a-l
and 10a-l has been successfully performed in high yields through the reaction of aromatic aldehydes, β-dicarbonyl
compound, urea/thiourea/guanidine hydrochloride by using potassium phthalimide (PPI) as organocatalyst under solventfree
conditions under microwave irradiation at 300 W. PPI has been introduced as an efficient and biodegradable
organocatalyst in Biginelli condensation with excellent reusability. The good yield of products, fast reaction time, simple
work-up procedure, as well as usage of nontoxic, reusable, and easily recoverable catalyst under magnetic starring have been
counted as advantages of the applied process. This organocatalyst can be removed after completion of reaction and reused
several times under the same reaction conditions without significant loss of catalyst activity. The anti-microbial activity of
all newly synthesised Biginelli products has been investigated against a variety of microorganisms such as E. coli, S. aureus,
S. pyogenes, P. aeruginosa, C. albicans, A. niger and A. clavatus
 
Date 2023-06-15T06:42:40Z
2023-06-15T06:42:40Z
2023-06
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62033
https://doi.org/10.56042/ijc.v62i6.2523
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(06) [June 2023]