Microwave-assisted synthesis of -CF3 functionalized 3,4-dihydropyrimidinone/thione/imine derivatives by using potassium phthalimide (PPI) as a green and reusable organocatalyst and their anti-microbial evaluation
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Title |
Microwave-assisted synthesis of -CF3 functionalized 3,4-dihydropyrimidinone/thione/imine derivatives by using potassium phthalimide (PPI) as a green and reusable organocatalyst and their anti-microbial evaluation
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Creator |
Odiya, Suresh P
Das, Siva Prasad Boruah, Jeena Jyoti |
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Subject |
Biginelli reaction
-CF3 functional group 3,4-Dihydropyrimidinone/thione/imine derivatives Potassium phthalimide (PPI) One-pot synthesis Microwave irradiation Solvent-free Anti-microbial activity |
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Description |
600-617
One-pot synthesis of novel -CF3 functional group containing 3,4-dihydropyrimidinone/thione/imine derivatives 8a-l, 9a-l and 10a-l has been successfully performed in high yields through the reaction of aromatic aldehydes, β-dicarbonyl compound, urea/thiourea/guanidine hydrochloride by using potassium phthalimide (PPI) as organocatalyst under solventfree conditions under microwave irradiation at 300 W. PPI has been introduced as an efficient and biodegradable organocatalyst in Biginelli condensation with excellent reusability. The good yield of products, fast reaction time, simple work-up procedure, as well as usage of nontoxic, reusable, and easily recoverable catalyst under magnetic starring have been counted as advantages of the applied process. This organocatalyst can be removed after completion of reaction and reused several times under the same reaction conditions without significant loss of catalyst activity. The anti-microbial activity of all newly synthesised Biginelli products has been investigated against a variety of microorganisms such as E. coli, S. aureus, S. pyogenes, P. aeruginosa, C. albicans, A. niger and A. clavatus |
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Date |
2023-06-15T06:42:40Z
2023-06-15T06:42:40Z 2023-06 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62033 https://doi.org/10.56042/ijc.v62i6.2523 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJC Vol.62(06) [June 2023]
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