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A study on synthesis, antioxidant, anticancer activities and docking study of novel benzimidazoloyl thiazole derivatives

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Title A study on synthesis, antioxidant, anticancer activities and docking study of novel benzimidazoloyl thiazole derivatives
 
Creator V S, Chithra
J, Brindha
Mariappan, A
Simon, Turibius
F, Abbs Fen Reji T
 
Subject Antioxidant
DPPH
Docking
Adenocarcinoma
MTT assay
 
Description 568-574
2-(Substituted-amino)-5-(1-methylbenzimidazol-2-oyl)thiazoles have been synthesized by the reaction of 2-(2-
bromoacetyl)-1-methylbenzimidazole and 1-(substituted-amino)-3-(N,N-dimethylimidoyl)thioureas in the presence of triethyl
amine. The structure of the newly synthesized benzmidazoloyl thiazole analogues have been confirmed by spectroscopic
techniques. The in vitro antioxidant activity has been studied using DPPH assay and anticancer activity has been studied using
MTT assay against human colon adenocarcinoma cells. In silico studies have been performed to predict the binding modes of
the compounds with the cyclin-dependent kinase protein 5FGK. It is evident from the current results that all the synthesized
compounds exhibit remarkable antioxidant and anticancer potential.
 
Date 2023-06-15T06:59:46Z
2023-06-15T06:59:46Z
2023-06
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62036
https://doi.org/10.56042/ijc.v62i6.2514
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(06) [June 2023]