Record Details

Synthesis, molecular docking and anti-inflammatory potential of novel hydrazones of eugenol in tuberculosis treatment

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Synthesis, molecular docking and anti-inflammatory potential of novel hydrazones of eugenol in tuberculosis treatment
 
Creator Rohane, Sachin H
Redasani, Vivekkumar K
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
 
Subject Hydrazone
Molecular docking
Anti-inflammatory activity
 
Description 551-558
The hydrazone derivatives of eugenol have been designed and synthesized via esterification, hydrazination and treatment
with different aldehydes or ketones. All these compounds have been docked with 4COX and 3LN1 (COX-2 enzymes) using
Schrodinger v7.4. The compounds have been characterized by IR, 1H NMR and LCMS. The compounds have been
evaluated for their anti-inflammatory potential using in vivo carrageenan induced rat hind paw method and in vitro protein
denaturation. The study reveals that most compounds have significant anti-inflammatory activity. Tested compounds as per
literature prove that they show antitubercular activity. Among tested compounds, compounds 4, 34, 37 and 42 exhibit the
highest anti-inflammatory activity. The present study shows that anti-inflammatory activity of the novel hydrazone
derivatives of eugenol is strongly connected with the position of the substituent on aromatic aldehyde or ketone. As these
compounds possess both the activities, therefore they may be useful in tuberculosis treatment.
 
Date 2023-06-15T08:31:40Z
2023-06-15T08:31:40Z
2023-06
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62038
https://doi.org/10.56042/ijc.v62i6.2507
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(06) [June 2023]