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<p>Gastroprotective effect of <em>Indukanta ghritam </em>in Aspirin plus Pylorus ligation induced gastric ulcers in Wistar Albino rats – An experimental evaluation</p>

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Title Statement <p>Gastroprotective effect of <em>Indukanta ghritam </em>in Aspirin plus Pylorus ligation induced gastric ulcers in Wistar Albino rats – An experimental evaluation</p>
 
Added Entry - Uncontrolled Name Aggarwal, Punam ; Final year PG scholar, All India Institute of Ayurveda, New Delhi
R, Galib ; Department of Rasashastra and Bhaishajya Kalpana, All India Institute of Ayurveda, Sarita Vihar, New Delhi 110 076
Prajapati, P K ; Dr. Sarvepalli Radhakrishnan Rajasthan Ayurved University, Jodhpur 342 037, India
Nil
 
Uncontrolled Index Term Antioxidant activity, Gastric ulcer, Gastroprotective activity, Indukanta ghritam, Pylorus ligation, Ulcer index
 
Summary, etc. <p>Among various gastric diseases, peptic ulcer is commonly reported in practice. The exact aetiology is unknown however, offensive and defensive factors and no acid no ulcer theories are nearer to its aetiology. <em>Helicobacter pylori </em>(<em>H.</em> <em>pylori</em>) infection is one of the causative factors, responsible for Peptic Ulcer Disease (PUD). Various treatment modalities along with antacids, proton pump inhibitors, and H<sub>2</sub>-receptor antagonists etc. are available in conventional medical science but they have certain limitations as well as side effects. On the other hand, the traditional system of medicine may have the upper hand in such conditions. Various herbs, herbo-mineral and herbal formulations are described in Ayurveda for these conditions. <em>Indukanta ghritam</em> is one among the herbal formulations, which is mentioned in scheduled books of Drugs &amp; Cosmetics act, 1940 and <em>Sahasrayogam</em>. It is useful in various gastric diseases and its clinical efficacy is proven. However, experimental data on its gastro-protective activity is not available till date. Thus, the present study was conducted to assess its gastroprotective activity at two different dose levels (4.5 g/kg and 9.0 g/kg) in aspirin plus pylorus ligation-induced gastric ulcer model in wistar albino rats. The efficacy of the formulation was determined on the basis of ulcer index, gastric volume, pH of gastric juice, anti-oxidant parameters, and histopathology of the stomach. <em>Indukanta ghritam</em> at double therapeutic dose showed comparatively better results in comparison to standard treatment and therapeutic dose group inferring the therapeutic values of the <em>Ghritam</em> in cases of PUD<em>.</em></p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-06-26 16:48:20
 
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http://op.niscair.res.in/index.php/IJTK/article/view/36141
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 2 (2023): Indian Journal of Traditional Knowledge
 
Language Note en