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Effects of modified Bushen Huoxue Prescription combined with active immunotherapy on immunomodulatory functions and pregnancy outcomes of patients with unexplained recurrent spontaneous abortion

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Title Effects of modified Bushen Huoxue Prescription combined with active immunotherapy on immunomodulatory functions and pregnancy outcomes of patients with unexplained recurrent spontaneous abortion
 
Creator Song, Qingxia
Miao, Li
Meng, Xianze
Sun, Fengdan
Xu, Dan
 
Subject Active immunotherapy
Astragalus membranaceus
Atractylodes macrocephala
Dipsacus asper
Interleukin
T lymphocytes
Taxillus chinensis
Traditional Chinese medicine
 
Description 585-591
Recurrent spontaneous abortion (RSA) is a common pregnancy
disease mostly occurring in the first trimester of pregnancy, and
unexplained RSA (URSA) occurs in approximately 40% of RSA
patients even after careful examination. Here, we assessed the
effects of modified Bushen Huoxue Prescription combined with
active immunotherapy on immunomodulatory functions and
pregnancy outcomes of URSA patients. Ninety-six eligible URSA
patients were randomly divided into control and experimental
groups (n=48). Active immunotherapy was performed for control
group, while experimental group were treated with modified
Bushen Huoxue Prescription combined with active immunotherapy.
Counts of peripheral blood helper T lymphocytes 17 (Th17) and
regulatory T lymphocytes (Treg), levels of inflammatory factors
interleukin-4 (IL-4), IL-10 and IL-17, and mRNA expression levels
of retinoic acid-related orphan receptor γt (RORγt) and forkhead
box P3 (FoxP3) were compared. Compared with before treatment,
ratios of Th17/CD4+ cells and Th17/Treg, IL-17 level and RORγt
mRNA level decreased, whereas ratio of Treg/CD4+ cells, IL-4 and
IL-10 levels and FoxP3 mRNA level increased in both groups after
treatment (P
 
Date 2023-06-28T09:48:32Z
2023-06-28T09:48:32Z
2023-07
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62126
https://doi.org/10.56042/ijeb.v61i07.2468
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(07) [July 2023]