Effects of modified Bushen Huoxue Prescription combined with active immunotherapy on immunomodulatory functions and pregnancy outcomes of patients with unexplained recurrent spontaneous abortion
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Title |
Effects of modified Bushen Huoxue Prescription combined with active immunotherapy on immunomodulatory functions and pregnancy outcomes of patients with unexplained recurrent spontaneous abortion
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Creator |
Song, Qingxia
Miao, Li Meng, Xianze Sun, Fengdan Xu, Dan |
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Subject |
Active immunotherapy
Astragalus membranaceus Atractylodes macrocephala Dipsacus asper Interleukin T lymphocytes Taxillus chinensis Traditional Chinese medicine |
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Description |
585-591
Recurrent spontaneous abortion (RSA) is a common pregnancy disease mostly occurring in the first trimester of pregnancy, and unexplained RSA (URSA) occurs in approximately 40% of RSA patients even after careful examination. Here, we assessed the effects of modified Bushen Huoxue Prescription combined with active immunotherapy on immunomodulatory functions and pregnancy outcomes of URSA patients. Ninety-six eligible URSA patients were randomly divided into control and experimental groups (n=48). Active immunotherapy was performed for control group, while experimental group were treated with modified Bushen Huoxue Prescription combined with active immunotherapy. Counts of peripheral blood helper T lymphocytes 17 (Th17) and regulatory T lymphocytes (Treg), levels of inflammatory factors interleukin-4 (IL-4), IL-10 and IL-17, and mRNA expression levels of retinoic acid-related orphan receptor γt (RORγt) and forkhead box P3 (FoxP3) were compared. Compared with before treatment, ratios of Th17/CD4+ cells and Th17/Treg, IL-17 level and RORγt mRNA level decreased, whereas ratio of Treg/CD4+ cells, IL-4 and IL-10 levels and FoxP3 mRNA level increased in both groups after treatment (P |
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Date |
2023-06-28T09:48:32Z
2023-06-28T09:48:32Z 2023-07 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62126 https://doi.org/10.56042/ijeb.v61i07.2468 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJEB Vol.61(07) [July 2023]
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