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Effect of external washing with self-made Xiaofeng Jiedu powder on expressions of serum inflammatory cytokines in patients with cutaneous adverse events induced by programmed cell death protein 1 inhibitor

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Title Effect of external washing with self-made Xiaofeng Jiedu powder on expressions of serum inflammatory cytokines in patients with cutaneous adverse events induced by programmed cell death protein 1 inhibitor
 
Creator Guo, Junhua
Chen, Wen
Hu, Keke
Jiang, Lu
 
Subject PD-1 inhibitor
Traditional Chinese medicine
Tumor
 
Description 578-584
Wide application of programmed cell death protein 1 (PD-1)
inhibitor for tumor treatment has led to increased immune-related
adverse events (irAEs), particularly cutaneous irAE. In this study,
we assessed the effects of external washing with self-made
Xiaofeng Jiedu powder on the expressions of serum inflammatory
cytokines in patients with cutaneous adverse events (AEs) induced
by PD-1 inhibitor. Fifty-six tumor patients with cutaneous AEs
induced by PD-1 inhibitor were randomly divided into
observation and control groups (n=28). The control group
underwent routine treatment with PD-1 inhibitor and oral
administration with cetirizine, while the observation group
received PD-1 inhibitor and soaking and fumigation by Xiaofeng
Jiedu powder in the affected skin once in the morning and once in
the evening. The levels of serum interleukin-6 (IL-6), IL-10, and
immunoglobulin E (IgE) were detected before and after treatment.
After treatment, the disease control rate of the observation group
was higher than that of the control group (P
 
Date 2023-06-28T09:51:00Z
2023-06-28T09:51:00Z
2023-07
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62127
https://doi.org/10.56042/ijeb.v61i07.2464
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(07) [July 2023]