Clinical features and biochemical parameters influencing mortality in COVID-19 patients — Retrospective study from Telangana, India
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Title |
Clinical features and biochemical parameters influencing mortality in COVID-19 patients — Retrospective study from Telangana, India
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Creator |
Sabeena, Sumayya Zainab
Pathy, Archana Luqman, Hajra Sreedevi, NN Khan, Siraj Ahmed K, Madhulatha Bhaskar, M Vijaya Baba, KSS Sai Durga, Padmaja Noorjahan, M |
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Subject |
Das
Uttam Saha Tanmay Babu Anindita Sinha Ray Dilip Kumar Ghosh Rita Das Subir Kumar |
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Description |
558-567
The common Giant Pigweed or Black Pigweed Trianthema portulacastrum L.is a well-known hepatoprotactant against chemical-induced toxicity. In this study, we evaluated the radioprotective activity of T. portulacastrum stem extract in Swiss albino mice through survival assay and confirmed by histopathology of the liver and jejunum. We observed that at higher concentrations (200 mg/kg body wt.) of extract, the survival of mice was 20% higher. The mechanism of protection was evaluated by endogenous colony-forming assay, bone marrow cell count, membrane integrity, and antioxidant enzymes of the liver. Histopathology of the liver and jejunum revealed that irradiated animals to have suffered loss of normal architecture of the liver in the form of hepatic sinusoid dilation and neutrophil infiltration, and distorted structure of villi in the jejunum of mice was observed. Pre-treatment of mice with extracts of Trianthema portulacastrum (50, 100 and 200 mg/kg body wt.) attenuated the effects of radiation in a dose-dependent manner. Further, the increased spleen colony numbers and augmented number of bone marrow cells in extract pre-treated mice, in comparison with untreated irradiated mice suggest the protective activity of T. portulacastrum. The treated group of mice also showed increased activities of antioxidant enzymes measured in tissue homogenates of the liver as compared to the untreated irradiated controls. Our present study demonstrated dose-dependent radioprotective property of T. portulacastrum against membrane damage. |
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Date |
2023-06-28T10:00:15Z
2023-06-28T10:00:15Z 2023-07 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62129 https://doi.org/10.56042/ijeb.v61i07.2215 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJEB Vol.61(07) [July 2023]
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