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Clinical features and biochemical parameters influencing mortality in COVID-19 patients — Retrospective study from Telangana, India

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Title Clinical features and biochemical parameters influencing mortality in COVID-19 patients — Retrospective study from Telangana, India
 
Creator Sabeena, Sumayya Zainab
Pathy, Archana
Luqman, Hajra
Sreedevi, NN
Khan, Siraj Ahmed
K, Madhulatha
Bhaskar, M Vijaya
Baba, KSS Sai
Durga, Padmaja
Noorjahan, M
 
Subject Das
Uttam
Saha
Tanmay
Babu
Anindita Sinha
Ray
Dilip Kumar
Ghosh
Rita
Das
Subir Kumar
 
Description 558-567
The common Giant Pigweed or Black Pigweed Trianthema portulacastrum L.is a well-known hepatoprotactant against
chemical-induced toxicity. In this study, we evaluated the radioprotective activity of T. portulacastrum stem extract in Swiss
albino mice through survival assay and confirmed by histopathology of the liver and jejunum. We observed that at higher
concentrations (200 mg/kg body wt.) of extract, the survival of mice was 20% higher. The mechanism of protection was
evaluated by endogenous colony-forming assay, bone marrow cell count, membrane integrity, and antioxidant enzymes of
the liver. Histopathology of the liver and jejunum revealed that irradiated animals to have suffered loss of normal
architecture of the liver in the form of hepatic sinusoid dilation and neutrophil infiltration, and distorted structure of villi in
the jejunum of mice was observed. Pre-treatment of mice with extracts of Trianthema portulacastrum (50, 100 and 200
mg/kg body wt.) attenuated the effects of radiation in a dose-dependent manner. Further, the increased spleen colony
numbers and augmented number of bone marrow cells in extract pre-treated mice, in comparison with untreated irradiated
mice suggest the protective activity of T. portulacastrum. The treated group of mice also showed increased activities of
antioxidant enzymes measured in tissue homogenates of the liver as compared to the untreated irradiated controls. Our
present study demonstrated dose-dependent radioprotective property of T. portulacastrum against membrane damage.
 
Date 2023-06-28T10:00:15Z
2023-06-28T10:00:15Z
2023-07
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62129
https://doi.org/10.56042/ijeb.v61i07.2215
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(07) [July 2023]