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Systematic validation of anti-inflammatory activity of raw drug samples in Holostemma annulare (Roxb.) K. Schum

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Title Systematic validation of anti-inflammatory activity of raw drug samples in Holostemma annulare (Roxb.) K. Schum
 
Creator P S, Smitha Devi
P, Anusha
T S, Preetha
 
Subject Anti-inflammatory
COX
Holostemma annulare
LOX, Proteinase
Tuberous roots
 
Description 401-408
The tuberous roots of Holostemma annulare are utilized as the drug Jivanti in Ayurvedic medicine system. There is a
huge demand of root tubers of this plant by pharmacies. Conversely, there are reports concerning adulteration in market
samples of Jivanti resulting in damaging effect on the quality of drug formulations. Till now there is no significant study to
relate the source plants available in markets as Jivanti. A meticulous phytochemical profiling especially of the roots is still a
lacuna and no studies have been carried out yet regarding this. We focused on this concept and analyzed the antiinflammatory
activity by means of proteinase inhibition assay, as well as COX and LOX inhibition assays in the root
samples collected from homestead cultivation (HS) and from an authenticated trade shop in Thiruvananthapuram (TS).
Among the two samples, TS exhibited comparable anti-inflammatory activity to HS which further confirms the authenticity
of the genuine drug in the preparation of Ayurvedic formulations. The study provides a scientific rationale in using
Holostemma roots in traditional drug preparations for diseases linked with inflammation and also throw light in fortifying
molecular approaches in validating elite raw drugs in order to supplement genuine samples for pharma needs.
 
Date 2023-06-28T11:45:57Z
2023-06-28T11:45:57Z
2023-06
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/62173
https://doi.org/10.56042/ijtk.v22i2.34581
 
Language en
 
Relation Int. Cl.23: A61K 36/00, A61K 45/06, C12N 9/50
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.22(2) [April 2023]