Record Details

Gastroprotective effect of Indukanta ghritam in Aspirin plus Pylorus ligation induced gastric ulcers in Wistar Albino rats – An experimental evaluation

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Gastroprotective effect of Indukanta ghritam in Aspirin plus Pylorus ligation induced gastric ulcers in Wistar Albino rats – An experimental evaluation
 
Creator Aggarwal, Punam
R, Galib
Prajapati, P K
 
Subject Antioxidant activity
Gastric ulcer
Gastroprotective activity
Indukanta ghritam
Pylorus ligation
Ulcer index
 
Description 381-389
Among various gastric diseases, peptic ulcer is commonly reported in practice. The exact aetiology is unknown however,
offensive and defensive factors and no acid no ulcer theories are nearer to its aetiology. Helicobacter pylori (H. pylori)
infection is one of the causative factors, responsible for Peptic Ulcer Disease (PUD). Various treatment modalities along
with antacids, proton pump inhibitors, and H2-receptor antagonists etc. are available in conventional medical science but
they have certain limitations as well as side effects. On the other hand, the traditional system of medicine may have the
upper hand in such conditions. Various herbs, herbo-mineral and herbal formulations are described in Ayurveda for these
conditions. Indukanta ghritam is one among the herbal formulations, which is mentioned in scheduled books of Drugs &
Cosmetics act, 1940 and Sahasrayogam. It is useful in various gastric diseases and its clinical efficacy is proven.
However, experimental data on its gastro-protective activity is not available till date. Thus, the present study was
conducted to assess its gastroprotective activity at two different dose levels (4.5 g/kg and 9.0 g/kg) in aspirin plus pylorus
ligation-induced gastric ulcer model in wistar albino rats. The efficacy of the formulation was determined on the basis of
ulcer index, gastric volume, pH of gastric juice, anti-oxidant parameters, and histopathology of the stomach. Indukanta
ghritam at double therapeutic dose showed comparatively better results in comparison to standard treatment and therapeutic
dose group inferring the therapeutic values of the Ghritam in cases of PUD.
 
Date 2023-06-28T11:46:22Z
2023-06-28T11:46:22Z
2023-06
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/62175
https://doi.org/10.56042/ijtk.v22i2.36141
 
Language en
 
Relation Int Cl.23: A61K 36/00, A61K 45/00
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.22(2) [April 2023]