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Endemic and endangered ethno-herbal medicinal climber of Darjeeling hills (Edgaria darjeelingensis C.B. Clarke) is a treasure of anti-cancer molecules: A study on GC-MS analysis and probable biosynthetic pathways

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Title Endemic and endangered ethno-herbal medicinal climber of Darjeeling hills (Edgaria darjeelingensis C.B. Clarke) is a treasure of anti-cancer molecules: A study on GC-MS analysis and probable biosynthetic pathways
 
Creator Chakraborty, Sourav
Majumder, Soumya
Ghosh, Arindam
Bhattacharya, Malay
 
Subject Anti-cancer
Edgaria darjeelingensis
GC-MS
Metabolites
Pathway
 
Description 371-380
Carcinogenesis, oncogenesis or tumourigenesis is a complex biomolecular mechanism that could progressively transform
normal cells to malignant forms. Proper diet constituting natural fruits and vegetables enriched in bioactive components can
reduce the risk factors of several forms of human cancer and other critical ailments. Endemic and endangered
Cucurbitaceous climber of Darjeeling hills, Herpetospermum darjeelingense (C.B. Clarke) H. Schaef. & S.S. Renner
[Edgaria darjeelingensis C.B. Clarke] is a repository of bioactive anti-cancer metabolites as depicted by the presence of
fourteen anti-carcinogenic molecules explored via GC-MS analysis, which could potentially minimize the threats of various
forms of cancer. The anti-cancer compounds cover about 79.22% of total GC-MS area percentage out of the total thirty four
compounds detected. The explored cellular biosynthesis pathway of these anti-carcinogenic metabolites seems to follow a
systemic metabologenesis pattern that may be required for the day-to-day survival of the plant and not a mere chance factor,
which could have stressed the plant to produce those biochemical molecules. Isolation, pharmaceutical screening of these
compounds and their medical application can revolutionise the dimension of the global cancer research in the near future.
 
Date 2023-06-28T11:50:15Z
2023-06-28T11:50:15Z
2023-06
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/62176
https://doi.org/10.56042/ijtk.v22i2.38484
 
Language en
 
Relation Int. Cl.23: A61K 36/00, A61K 45/00
 
Publisher NIScPR-CSIR,India
 
Source IJTK Vol.22(2) [April 2023]