Record Details

Clinical features and biochemical parameters influencing mortality in COVID-19 patients — Retrospective study from Telangana, India

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Clinical features and biochemical parameters influencing mortality in COVID-19 patients — Retrospective study from Telangana, India
 
Creator Sabeena, Sumayya Zainab
Pathy, Archana
Luqman, Hajra
Sreedevi, NN
Khan, Siraj Ahmed
K, Madhulatha
Bhaskar, M Vijaya
Baba, KSS Sai
Durga, Padmaja
Noorjahan, M
 
Subject Comorbidity
Healthcare workers
SARS-CoV-2
 
Description 568-572
The coronavirus disease COVID-19 caused by SARS-CoV-2 was
a worldwide public health emergency which affected millions of
people including frontline healthcare workers too. We evaluated
the clinical features and biochemical investigations in COVID-19
affected healthcare workers (HCW) admitted to NIMS Intensive
care unit (ICU) including survivors and non-survivors to identify
risk factors for mortality. We did a retrospective study of 78 HCW
with RTPCR confirmed COVID-19 infection admitted in ICU
between July and November, 2020. Subjects were grouped into
survivors and non-survivors. Clinical features and biochemical
investigations were compared. Survival analysis was performed to
analyze the risk factors of mortality. Out of the 78 patients
admitted to ICU, the majority were males (64%). Non-survivor
patients were older with a median age of 64 years. There were
significantly higher proportion of females (59%) in non-survivors.
COVID-19 non-survivors had significantly more incidence of
cardiovascular disease and also higher blood levels of AST, CPK,
CRP, D-dimer, IL-6, LDH, urea, NTproBNP and procalcitonin.
Hazard’s ratios showed that the mortality risk was significantly
higher and survival was significantly lower in patients more than
60 years in age, females and those having IL-6 >40.06 pg/mL,
LDH >461U/L, NTproBNP >1188 pg/mL, procalcitonin >0.5 pg/mL,
urea >67 mg/dL, creatinine >1.3 mg/dL, D-dimer >573 ng/mL,
ferritin >1488 ng/mL, andCPK >191U/L. Our study identified that
the mortality risk was significantly higher and survival was
significantly lower in patients older age group, females and those
having higher IL-6, LDH, NTproBNP, procalcitonin, urea,
creatinine, D-dimer, ferritin and CPK. Determination of specific
clinical and biochemical features as above would help in better
understanding of the pathophysiology, prognosis and appropriate
intervention for potential outcomes.
 
Date 2023-06-30T05:31:15Z
2023-06-30T05:31:15Z
2023-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62209
https://doi.org/10.56042/ijeb.v61i07.2215
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(07) [July 2023]