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Association of immune status with haematology and inflammatory markers in treatment naïve HIV positive patients from a tertiary health care institute

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Title Association of immune status with haematology and inflammatory markers in treatment naïve HIV positive patients from a tertiary health care institute
 
Creator Kavitha, Kasipandy
Nayak, Saurav
Saharia, Gautom Kumar
Singh, Arvind Kumar
Mangaraj, Manaswini
 
Subject Acquired immuno deficiency syndrome (AIDS)
Anaemia
Anti retroviral therapy
ART naïve
C-Reactive Protein
Ferritin
Human immunodeficiency virus (HIV)
 
Description 505-510
High and low serum ferritin level in HIV patients is associated with the progression of disease with lowering of CD4 cell
count in both adults and children. Elevated C-Reactive protein (CRP) has been a better predictor of child mortality and
maternal disease progression to Acquired immuno deficiency syndrome (AIDS). Data related to ferritin, CRP together with
anaemia and immune status in early stage of ART naïve HIV infection is scarce. Here, we evaluated haematological
parameters, inflammatory markers like serum ferritin, CRP level and their association with immune status in Antiretroviral
therapy (ART) naïve HIV positive cases. After obtaining written consent, 55 screening test (Meriscreen) positive &
HIV-TRIDOT confirmed, antiretroviral treatment naïve patients above 18 years from both gender were included in the
study. Serum ferritin, CRP and other haematological parameters were analysed along with CD4 and CD8 count. Anaemia
found prominent in group having CD4 count less than 200 cells/μL with a significant fall in Hb%. Inflammatory parameters
ferritin and CRP analyzed with respect to CD4 cells documented reverse phenomena in these cases. Significant inverse
relation of ferritin with Hb%, total WBC and absolute lymphocyte count points towards concurrent presence of anaemia and
leukopenia with inflammation in HIV cases. The results suggest that inflammatory markers like ferritin induced by
cytokines may be considered as an auxiliary parameter for assessing disease severity in HIV positive cases at time of
diagnosis for early therapeutic intervention.
 
Date 2023-06-30T05:54:34Z
2023-06-30T05:54:34Z
2023-06
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62217
https://doi.org/10.56042/ijeb.v61i07.2323
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(07) [July 2023]