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Simulation of Optical Characteristics of a Breast Tumor Incorporated with Silica Coated Gold Nanorods

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Title Simulation of Optical Characteristics of a Breast Tumor Incorporated with Silica Coated Gold Nanorods
 
Creator Vikas
Gautam, Rizul
Soni, Sanjeev
 
Subject Silica coating
Gold nanorods
Plasmonic photothermal
Optical absorption cross-section
 
Description 554-559
Silica coated nanoparticles are advantageous in terms of enhanced biocompatibility, colloidal and thermal stability as
well as ease of surface functionalization for use in various biomedical applications. Specifically, for plasmonic photothermal
therapeutics and photothermally modulated drug delivery, it is always desired to have maximum absorption of the incident
EM radiation by the nanoparticles. So, it is required to quantify the absorption cross-section (σabs) of silica coated gold
nanorods (GNRs) of varying silica coating thickness. Here, the optical properties of silica coated GNRs embeded in breast
tumor like medium are computed for 10×41 nm GNRs which are considered to be coated (dense) with silica thickness range
of 1-20 nm. Also, periodic and random spatial distributions of these GNRs within the tumor are accounted for calculating
the effect of silica thickness on the overall optical properties. For this, finite element method is used wherein the propagation
of incident elecromagnetic field is assumed to be perpendicular to the longitudinal axis of GNRs. Results show that for
GNRs coated with silica thickness of 1 nm, the plasmonic wavelength is red-shifted by 40 nm as compared to bare GNRs.
Furthermore, on increasing the silica thickness from 2-20 nm, plasmonic wavelength is red-shifted by 24 nm.The absorption
and scattering cross-section are increased by ~4.5% and ~8% for GNR coated with 1 nm silica as compared to the bare
GNR. Further, it is seen that the scattering cross-section of the media is significantly enhanced by ~26% with an increase in
silica thickness from 1-20 nm, while there is no significant change in absorption cross-section for higher silica coating
thickness up to 20 nm. Considering the spatial distribution of GNRs within the tumor, the σabs values is increased by ~44%
for periodically distributed silica coated GNRs as compared to random distribution within the tumor domain. Also, it is
observed that the electric field is confined close to the Gold-Silica interface for lower thickness of the silica coating. These
discussed results are useful for the selection of silica coating thickness on GNRs for the biomedical applications such as
plasmonic photothermal therapy and photothermally modulated drug delivery.
 
Date 2023-07-03T10:52:09Z
2023-07-03T10:52:09Z
2023-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62240
https://doi.org/10.56042/ijpap.v61i7.101
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJPAP Vol.61(07) [July 2023]