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In silico analysis of cubebinol for evaluating its efficiency against menacing respiratory ailments

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Title In silico analysis of cubebinol for evaluating its efficiency against menacing respiratory ailments
 
Creator S, Hari Lakshmi
Devasena, T
 
Subject Cubebinol
Molecular docking
Phytochemical
Piper cubeba
Respiratory diseases
 
Description 448-460
Over the recent decade a survey states that the advent of respiratory diseases had took a rapid transmittance and
transformation rate. The mortality and the morbidity rates were also exorbitant. Piper cubeba is one of the traditional plant
species belongs to Piperacea family, which possess good antibacterial activity. The plant comprise of several
phytocomponent one among which is cubebinol, whose specific activities have not been much explored. Hence it is
subjected in this research and its antibacterial efficiency is investigated through virtual screening technique. Techniques like
Auto dock, Discovery studio, Pymol are evolved in the investigation to know the unknown nature of the phytocomponent by
analyzing its binding affinity along with the major respiratory disease causing organism’s macromolecules. Thus it
manifests the efficiency and the potency of the plant phytocomponent, which is found to be better than that of the readily
available and commercially consumed drug molecules. By both the pharmacokinetic test as well as the docking validation
we found that the docked ligand compound cubebinol is a potent drug against several fatal bacterial respiratory diseases.
 
Date 2023-07-11T05:39:17Z
2023-07-11T05:39:17Z
2023-07
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/62287
https://doi.org/10.56042/ijct.v30i4.71631
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJCT Vol.30(4) [July 2023]