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Pharmacological and therapeutic potential of honey bee antimicrobial peptides

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Title Pharmacological and therapeutic potential of honey bee antimicrobial peptides
 
Creator Roy, Dinata
Arati, Chettri
Manikandan, Bose
Abinash, Giri
Nisa, Nisekhoto
Bhanushree, Baishya
Saeed-Ahmed, Laskar
Bidanchi, Rema Momin
Pori, Buragohain
Khushboo, Maurya
Indira, Sonar
Roy, Vikas Kumar
Rao, KRS Sambasiva
Gurusubramanian, Guruswami
 
Subject AMPs
Databases
Honey bees
Signaling pathways
Therapeutic applications
 
Description 365-384
Honey bees (Apidae: Apini) and stingless bees (Apidae: Meliponini) act as the main pollinators for many wild and
cultivated tropical plants, playing a vital role in the ecology, economy, and culture. Honey bees and stingless bees are one of
the major sources of antimicrobial peptides/proteins (AMPs) synthesized in fat bodies and blood cells of bees. Bee AMPs
are a class of small peptides having amino acid residues between 9 and 340, classified based on source, activity, structural
characteristics, and amino acid-rich species. AMP's have a wide range of inhibitory effects against bacteria, fungi, parasites,
and viruses. Four antimicrobial peptide families, i.e., apidaecins (proline-rich), abaecin (proline-rich), hymenoptaecin
(glycine-rich), and defensin (cystine-rich) are synthesized in the haemolymph, signifying a broad spectrum of antimicrobial
activity. Jelleines (I-IV), royalisin, apisimin (serine-valine-rich peptide), 10 HDA, apalbumin, and apisin, which are present
in royal jelly, have antimicrobial, mast cell degranulating, and hemolysis activity. Bee venom also contains several bioactive
peptides, such as apamin (leucine-cystine-rich), melittin (leucine-alanine-rich), melectin (lysine-rich), adolapin, secapin
(proline-rich), and tertiapin (cystine-lysine-rich). Currently, AMPs databases are displaying an essential role in exploration,
identification, characterization, and annotation. Several AMPs databases (CAMP, DRAMP, APD, InverPep, LAMP,
ADAPTABLE, ADAM, AntiBP, AMPer, AVPpred, EFC-FCBF, and class AMP) are open-access resources that have been
developed to enhance research on antimicrobial peptides. Bee immune responses are composed of a multifaceted group of
individual immune mechanisms and special types of behavioral adaptations. Given the importance of drug discovery from
honey bee AMPs, this review is aimed at providing an exhaustive screening of the AMPs detected in honey and honeybee
products and their classification, databases, computational tools, physicochemical properties, signaling pathways,
pharmaceutical and clinical uses, application status, prospects, and problems to be solved
 
Date 2023-07-20T06:34:19Z
2023-07-20T06:34:19Z
2023-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62307
https://doi.org/10.56042/ijbb.v60i5.552
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(05) [May 2023]