Record Details

Oxidation of paracetamol by N-chloro-p-toluene sulfonamide (Chloramine-T) in aqueous acid perchlorate medium: A kinetic and mechanistic pathway

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Oxidation of paracetamol by N-chloro-p-toluene sulfonamide (Chloramine-T) in aqueous acid perchlorate medium: A kinetic and mechanistic pathway
 
Creator Pareek, Deepmala
Sailani, Riya
Bhasin, Menka
Goswami, Arkja
Manav, Navneet
 
Subject Chloramine-T
Mechanism
Oxidation
Paracetamol
Reaction kinetics
 
Description 780-787
Kinetics and mechanism of oxidation of paracetamol by N-chloro-p-toluene sulfonamide (chloramine-T) have been studied in acid medium. Accounting for all such observations, a plausible reaction mechanism has been suggested. The activation parameters such as energy and entropy of activation have been calculated to be (58.63 ± 0.91) kJ mol−1
and (−88.75 ± 4.54) J K−1 mol−1 respectively employing Eyring equation. The stoichiometry of the reaction has been observed to be two moles of the oxidant for a mole of the substrate. The rate of the reaction is retarded by toluene-
p-sulfonamide as well as hydrogen ion concentration. The oxidation product of paracetamol has been spectrally confirmed to be quinine oxime. To further support our proposed mechanism, density functional theory (DFT) computations at
M06-2X/6-31G(d,p) level of theory have been performed, showing that activation energy barriers predict the same reactivity trend as shown by the kinetic experiments.
 
Date 2023-07-20T07:19:07Z
2023-07-20T07:19:07Z
2023-07
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62309
https://doi.org/10.56042/ijc.v62i7.3832
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(07) [July 2023]