Synthesis of novel glycosyl thiadiazole triazines and screening for antimicrobial activity
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Title |
Synthesis of novel glycosyl thiadiazole triazines and screening for antimicrobial activity
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Creator |
Ghayalkar, Renu B
Deshmukh, Shirish P |
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Subject |
Glycosylisocyanates
Thiadiazole Glycosyl Carbamides Glycosyl Thiadiazolotriazine Antimicrobial Activity |
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Description |
746-754
In continuation to our search for a new bioactive potent molecule, we have synthesized several new 1-glycosyl-3-(5- phenyl-[1,3,4]thiadiazolyl)-carbamides by the interaction of various glycosyl isocyanates with 2-amino-5-phenyl-[1,3,4]- thiadiazole in acetone medium. Furthermore, several novel 6-glycosyl-2-phenyl-5-phenylimino-5,6-dihydro- [1,3,4]thiadiazolo [3,2-a][1,3,5]triazin-7-one have been synthesized by the interaction of phenyl isocyanodichloride and 1-glycosyl-3-(5-phenyl-[1,3,4]thiadiazolyl)-carbamides. The identities of these newly synthesized glycosyl carbamides and glycosyl thiadiazolo triazine have been established based on usual chemical transformations and IR, 1H and 13C NMR and mass spectral studies and these will be assayed for their antibacterial activity against common pathogens like E. coli, S. aureus, P. vulgaris, S. typhi, K. pneumoniae, Pseudomonas aeruginosa and for antifungal activity against Aspergillus niger and Candida albican to get potent bioactive molecule. |
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Date |
2023-07-20T08:30:22Z
2023-07-20T08:30:22Z 2023-07 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62313 https://doi.org/10.56042/ijc.v62i7.3734 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(07) [July 2023]
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