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Synthesis of novel glycosyl thiadiazole triazines and screening for antimicrobial activity

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Title Synthesis of novel glycosyl thiadiazole triazines and screening for antimicrobial activity
 
Creator Ghayalkar, Renu B
Deshmukh, Shirish P
 
Subject Glycosylisocyanates
Thiadiazole
Glycosyl Carbamides
Glycosyl Thiadiazolotriazine
Antimicrobial Activity
 
Description 746-754
In continuation to our search for a new bioactive potent molecule, we have synthesized several new 1-glycosyl-3-(5-
phenyl-[1,3,4]thiadiazolyl)-carbamides by the interaction of various glycosyl isocyanates with 2-amino-5-phenyl-[1,3,4]-
thiadiazole in acetone medium. Furthermore, several novel 6-glycosyl-2-phenyl-5-phenylimino-5,6-dihydro-
[1,3,4]thiadiazolo [3,2-a][1,3,5]triazin-7-one have been synthesized by the interaction of phenyl isocyanodichloride and
1-glycosyl-3-(5-phenyl-[1,3,4]thiadiazolyl)-carbamides. The identities of these newly synthesized glycosyl carbamides and
glycosyl thiadiazolo triazine have been established based on usual chemical transformations and IR, 1H and 13C NMR and
mass spectral studies and these will be assayed for their antibacterial activity against common pathogens like E. coli,
S. aureus, P. vulgaris, S. typhi, K. pneumoniae, Pseudomonas aeruginosa and for antifungal activity against Aspergillus
niger and Candida albican to get potent bioactive molecule.
 
Date 2023-07-20T08:30:22Z
2023-07-20T08:30:22Z
2023-07
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62313
https://doi.org/10.56042/ijc.v62i7.3734
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(07) [July 2023]