-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin
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Title |
-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin
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Creator |
Kantar, Günay Kaya
Baltaş, Nimet Şahin, Onur Şaşmaz, Selami |
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Subject |
Azaphthalocyanine
Vanillin -Glucosidase inhibition |
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Description |
728-734
Vanillin substituted novel zinc(II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their α-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised using a combination of FT-IR, ¹H and ¹³C NMR, UV-Vis, MS and elemental analysis. The crystal structures of starting pyrazine compounds 1 and 2 have also been determined by the single crystal diffraction technique. All newly synthesized compounds have been evaluated for their in vitro inhibitory activity against -glucosidase and all of them have more inhibitory effect when compared to acarbose as reference compound. Especially, compound 2 shows the most significant -glucosidase inhibition. IC50 values of compound 2 and acarbose, which is known as α-glucosidase inhibitor used as anti-diabetic drug, have been found to be 6.01±0.16 and 9.52±0.23 μg/mL, respectively. |
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Date |
2023-07-20T08:38:01Z
2023-07-20T08:38:01Z 2023-07 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62315 https://doi.org/10.56042/ijc.v62i7.3730 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(07) [July 2023]
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