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-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin

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Title -Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin
 
Creator Kantar, Günay Kaya
Baltaş, Nimet
Şahin, Onur
Şaşmaz, Selami
 
Subject Azaphthalocyanine
Vanillin
-Glucosidase inhibition
 
Description 728-734
Vanillin substituted novel zinc(II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their
α-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised using a combination of
FT-IR, ¹H and ¹³C NMR, UV-Vis, MS and elemental analysis. The crystal structures of starting pyrazine compounds 1 and
2 have also been determined by the single crystal diffraction technique. All newly synthesized compounds have been
evaluated for their in vitro inhibitory activity against -glucosidase and all of them have more inhibitory effect when
compared to acarbose as reference compound. Especially, compound 2 shows the most significant -glucosidase inhibition.
IC50 values of compound 2 and acarbose, which is known as α-glucosidase inhibitor used as anti-diabetic drug, have been
found to be 6.01±0.16 and 9.52±0.23 μg/mL, respectively.
 
Date 2023-07-20T08:38:01Z
2023-07-20T08:38:01Z
2023-07
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62315
https://doi.org/10.56042/ijc.v62i7.3730
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(07) [July 2023]