Record Details

Computational Insights into the interaction of Piperine with Immune Regulatory Proteins: A Docking Study

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Computational Insights into the interaction of Piperine with Immune Regulatory Proteins: A Docking Study
 
Creator Jain, Swati
Prajapati, Harshal
Ganeshpurkar, Aditya
Dubey, Nazneen
Singh, Sukhwant
 
Subject Alkaloids
COX-2
Cytokines
Piperine
 
Description 478-484
The natural products, such as plant, mineral, and animal compounds, have been used for medicinal purposes for
centuries. The use of medicinal herbs to modulate immune function has a rich history, and natural products serve as the
foundation for contemporary pharmaceutical ingredients. Immunomodulation is the process of modifying an individual's
immune system by interfering with its normal processes. Immunomodulators derived from natural sources have been
extensively studied in order to modify the immune system and prevent illness.One such natural product that has been studied
for its immunomodulatory properties is Piperine. Piperine is a chemical compound found in black pepper and other spices,
and it has been found to have anti-inflammatory and analgesic properties in animal studies. In this context, present study is
basedon insilico docking studies to investigate the interaction of Piperine with various chemokines and inflammatory
pathways. The results of these docking studies demonstrated that Piperine exhibited an excellent interaction with targets
such as TNF-α, IL-1β, IL-6, and COX-2. This research provides insight into the development of new compounds for
immunomodulation and the management of inflammatory illnesses. However, further research on Piperine and related
flavonoids is necessary to assess their safety as a potential immunomodulatory agent.
 
Date 2023-07-28T09:56:14Z
2023-07-28T09:56:14Z
2023-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62361
https://doi.org/10.56042/ijbb.v60i6.1624
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.60(06) [June 2023]