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Down-regulation of miRNA 451a promotes many oncogenic signaling pathways in breast cancer patients

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Title Down-regulation of miRNA 451a promotes many oncogenic signaling pathways in breast cancer patients
 
Creator Saeed, Hina
Ejaz, Samina
 
Subject CDKN2B
CDKN2D
FOXO signaling
microRNA451a
PSMB8
RAB5A
UCK1
 
Description 467-477
The present study was designed to investigate the expression status of the micro RNA 451a (miR-451a) in BC patients through multi-layered bioinformatics analysis. The miR-451a was down-regulated in BC patients and through the KEGG pathway analysis we were able to find 8 genes (CDKN2B, CDKN2D, ATF2, EIF2A3K, RAB5A, CAV1, UCK1, and PMM2) encoded molecules of which can potentially participate in different pathways like cell cycle, FOXO signaling pathway, influenza A, Viral carcinogenesis, Endocytosis, HTLV-I infection, Metabolic pathways, and ubiquitination pathways. While PSMB8 acts as the major target of miR-451a and is involved in different pathways of cancer proliferation, metastasis, and growth. The PSMB8 protein is a component of the immuno-proteasome and participates in the ubiquitination-based degradation of the proteins. It’s concluded that miR-451a acts as a tumor suppressor molecule and its down-regulation turns on many oncogenic pathways and thus promotes cancer.
 
Date 2023-07-28T09:58:56Z
2023-07-28T09:58:56Z
2023-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62362
https://doi.org/10.56042/ijbb.v60i6.3096
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.60(06) [June 2023]