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Inhibitory activity of polyphenolic compound extracted from P. betel and T. aestivum with hepcidin for Iron deficiency anemia: An in silico approach

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Title Inhibitory activity of polyphenolic compound extracted from P. betel and T. aestivum with hepcidin for Iron deficiency anemia: An in silico approach
 
Creator Khan, Neha
Johri, Sonia
Paul, Nabomita
 
Subject 2,4-dihydroxybenzaldehyde
Catechin
Chlorogenic acid
Ferroportin
Hepcidin
 
Description 448-454
Anaemia is a condition that occurs when haemoglobin levels decrease below normal and a lower-than-normal number
of healthy red blood cells are produced. A newly identified iron regulator, hepcidin reveals the body's iron status and
demand for erythropoiesis to the intestine which modulates intestinal iron absorption. Hepcidin plays a significant role in the
iron regulatory system as it naturally binds to ferroportin which is the cellular iron expoter. The hepcidin was docked with
bioactive compounds in catechin, chlorogenic acid, T. aestivum grass and 2,4 dihydroxy benzaldehyde in P. betel leaves.
The aim of the current study is to investigate the interaction of bioactive compounds with hepcidin through molecular
docking. All three bioactive compounds revealed significant interaction with hepcidin. Catechin showed highest binding
energy (7.1 Kcal/mol) as compared to cholorogenic acid and 2,4 dihydroxy benzaldehyde.
 
Date 2023-07-28T10:03:55Z
2023-07-28T10:03:55Z
2023-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62364
https://doi.org/10.56042/ijbb.v60i5.147
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.60(06) [June 2023]