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Evaluation of Antioxidant and Anticancer Activity of Amino Acid Derived Schiff Bases and their Metal Complexes – A Review

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Title Evaluation of Antioxidant and Anticancer Activity of Amino Acid Derived Schiff Bases and their Metal Complexes – A Review
 
Creator Ancy, Rayappan Paustina
Thilaga, Ganeshmurthy
Sanguni, Ganesmoorthy
Gowri, Maruthapillai
 
Subject Antioxidant activity
Anticancer activity
Cisplatin/Carboplatin
 
Description 437-447
Simple condensation of an aldehyde or ketone with a primary amine, also known as an azomethine or an imine (-HC=N-)
bond, forms Schiff bases. Amino acids are organic compounds comprising a single carbon atom, known as α -a carbon atom,
along with an amino group (-NH2) and a carboxylic acid group(-COOH). Cancer leads to millions of deaths worldwide and
is expected to increase by 12.8 percent in 2025 compared to 2020. Additionally, our body needs antioxidants to reduce
harmful diseases, eliminate free radicals, and prevent oxidation. Schiff bases derived complexes tried to improve biological
activity. A novel class of Schiff bases generated from amino acids and their metal complexes exhibits an enhanced broad
spectrum of pharmacological actions. Their most significant medical applications include antibacterial, antifungal (including
anti-yeast), antiviral, antitumor, anti-inflammatory, antipyretic, antimalarial, anticancer, antioxidant, and anesthetic
properties. The finds of Schiff bases derived amino acids, and their complexes provide a range of activity rate that depends
on their orientation and metal atom. They need to be exposed further to other biological studies. The review includes
synthesizing, characterizing, and analyzing anticancer and antioxidant activity compounds. On critical evaluation, we
established that these studies show some effect on therapy and lower the risk of diseases.
 
Date 2023-07-28T10:05:36Z
2023-07-28T10:05:36Z
2023-07
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62365
https://doi.org/10.56042/ijbb.v60i6.2671
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.60(06) [June 2023]