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Evaluation of acute and subacute toxicity of Vernonia cinerea (L.) Less using mice model

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Title Evaluation of acute and subacute toxicity of Vernonia cinerea (L.) Less using mice model
 
Creator Johnson, Jimsy
Varghese, Leyon
 
Subject Acute toxicity
Ayurveda
Phytochemicals
Subacute toxicity
Swiss albino mice
 
Description 270-277
Vernonia cinerea (L.) Less is a medicinal plant distributed throughout India and is used traditionally for treating several
diseases. This study aimed to analyze the toxicological effects of ethyl acetate extract (VCEA) of this plant. Preliminary
phytochemical screening of VCEA was conducted by conventional methods. For acute toxicity studies, female Swiss albino
mice were treated with a single oral dose of 2000 mg/kg body weight of VCEA and observed for any changes in general
characters. For the subacute toxicity study, mice were treated (50 or 100 mg/kg body weight) consecutively for 28 days and
the haematological, biochemical, and histopathological changes were analysed. From the phytochemical analysis, it was
inferred that terpenoid content was more in the VCEA extract. No mortality or toxic effects were observed in the acute
study. Repeated dosage of VCEA at 50 mg/kg body weight did not impart any adverse effects in any of the parameters
assessed. The higher dosage (100 mg/kg body weight) made the animals slightly anaemic. Therefore a dose of up to
50 mg/kg body weight is recommended as safe for testing the pharmacological properties of VCEA in mice models.
 
Date 2023-07-31T09:47:34Z
2023-07-31T09:47:34Z
2023-07
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62375
https://doi.org/10.56042/ijnpr.v14i2.4211
 
Language en
 
Relation A61K 36/00, A61K 36/28, A61P
 
Publisher NIScPR-CSIR, India
NIScPR-CSIR, India
 
Source IJNPR Vol.14(2) [June 2023]