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Wound-healing potential of topical application of preparations from Noni (Morinda citrifolia L.) leaf extract

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Title Wound-healing potential of topical application of preparations from Noni (Morinda citrifolia L.) leaf extract
 
Creator Trieu, Ly Hai
Quynh, Dao Nguyen Nhu
Oanh, Nguyen Thi Kim
Thao, Lam Bich
Khoi, Nguyen Minh
Hieu, Tran Ba
Minh, Le Van
 
Subject Cream
Morinda citrifolia leaves
Ointment
Powder
Wound healing activity
 
Description 255-269
Developing products derived from medicinal herbs with wound-healing effects has been a current trend. This study was
set up to observe the wound healing efficiency of herbal preparations formulated from M. citrifolia leaf extract on mice. The
wound healing activity of cream, ointment, and powder preparations containing Noni leaf extract of 1% and 5% (w/w) was
investigated on the excision wound model. The potential preparation was continuously evaluated for rabbit skin irritation,
antioxidant activity, total flavonoid, and rutin contents. Results revealed that the topical application of Noni leaf extract
preparations treated groups increased remarkably wound contraction during 11 days of treatment. A cream containing
1% extract not only had the ability to significantly reduce the size of the wound but also regenerated the structure of the skin
histology at the wound area. Moreover, the cream showed safety following an acute dermal irritation study on rabbits as
well as an antioxidant effect via inhibition of DPPH and ABTS free radicals. The present study also identified the content of
total flavonoids and rutin markers in the cream. This research affirms the topical application of the cream containing
M. citrifolia leaf extract as a known wound healing factor from traditional medicine.
 
Date 2023-07-31T10:01:46Z
2023-07-31T10:01:46Z
2023-07
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62381
https://doi.org/10.56042/ijnpr.v14i2.4210
 
Language en
 
Relation A61K 36/00, A61K 36/74, A61K 127/00, A61P 17/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(2) [June 2023]