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Effect of curcumin on plasma TBARS and IL-6, adipose tissue AFABP-4 and liver FGF-21 in fructose-induced metabolic syndrome rats

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Title Effect of curcumin on plasma TBARS and IL-6, adipose tissue AFABP-4 and liver FGF-21 in fructose-induced metabolic syndrome rats
 
Creator Severcan, Suzan Muratoğlu
Koca, Gülce
Severcan, Çinar
Yilmaz, Canan
Paşaoğlu, ÖzgeTuğçe
Paşaoğlu, Hatice
 
Subject Curcuma longa
Fructose administration
Inflammation
Oxidative stress
Turmeric
 
Description 640-645
Elucidation of the positive effects of curcumin on oxidative damage and inflammation, as well as clarifying the parameters
related to adipose tissue and liver, would contribute furthermore to literature. Here, we have demonstrated the potential healing
effects of curcumin in rats with metabolic syndrome (MetS). Twenty-four adult male Wistar albino rats were selected for the
study. Only corn oil was administered to the control group rats, while corn oil and 20% fructose were administered to the MetS
group rats for eight weeks. The curcumin dose groups were administered 100 and 200 mg/kg of curcumin dissolved in corn oil
along with 20% fructose. Plasma TBARS, IL-6, adipose AFABP-4 and liver FGF-21 levels were determined using the ELISA
method. It was observed that plasma TBARS and IL-6 levels were significantly decreased in the 100 and 200 mg/kg curcumin
dose groups compared to the MetS group (P ≤0.008). Adipose tissue A-FABP-4 levels in the 200 mg/kg curcumin dose group
were significantly decreased compared to the MetS group (P ≤0.008). FGF-21 levels in the 100 mg/kg and 200 mg/kg curcumin
dose groups were significantly increased compared to the MetS group (P ≤0.008). The healing effects of curcumin
administration on MetS were effective on inflammation and lipid peroxidation. Curcumin administration decreased the adipose
tissue AFABP-4 levels and increased the liver FGF-21 levels.
 
Date 2023-07-31T09:57:09Z
2023-07-31T09:57:09Z
2023-07
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62379
https://doi.org/10.56042/ijeb.v61i08.3879
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.61(08) [August 2023]