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Extracellular matrix remodelling in rat heart in an unpredictable chronic mild stress model associated with diabetes

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Title Extracellular matrix remodelling in rat heart in an unpredictable chronic mild stress model associated with diabetes
 
Creator Dab, Houcine
Hamed, Said Ben
Hodroj, Wassim
Zourgui, Lazhar
 
Subject Cardiovascular disorder (CVD)
Comorbidity
Depression
Gelatinolytic activity
Fibronectin deposition
mRNA expression
matrix metalloproteinases (MMPs)
Plasminogen activator (t-PA)
Plasminogen inhibitor (PAI-1)
Social stress
 
Description 630-639
The coexistence of depression and diabetes is a serious challenge in cardiovascular disease. However, extracellular
matrix (ECM) under stress model associated or not with diabetes remains unknown. This study aims to investigate the
involvement of diabetes and unpredictable chronic mild stress (UCMS) on ECM remodelling. Rats were exposed to UCMS,
diabetes or combined treatment. mRNA expression of matrix metalloproteinases (MMP-2 and MMP-9), plasminogen
activator (t-PA) and inhibitor (PAI-1) was examined by Q-RT-PCR. ECM was determined by ELISA. MMP-2 and MMP-9
mRNA was lower in diabetes (P
 
Date 2023-07-31T09:59:58Z
2023-07-31T09:59:58Z
2023-07
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62380
https://doi.org/
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.61(08) [August 2023]