Extracellular matrix remodelling in rat heart in an unpredictable chronic mild stress model associated with diabetes
NOPR - NISCAIR Online Periodicals Repository
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Title |
Extracellular matrix remodelling in rat heart in an unpredictable chronic mild stress model associated with diabetes
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Creator |
Dab, Houcine
Hamed, Said Ben Hodroj, Wassim Zourgui, Lazhar |
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Subject |
Cardiovascular disorder (CVD)
Comorbidity Depression Gelatinolytic activity Fibronectin deposition mRNA expression matrix metalloproteinases (MMPs) Plasminogen activator (t-PA) Plasminogen inhibitor (PAI-1) Social stress |
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Description |
630-639
The coexistence of depression and diabetes is a serious challenge in cardiovascular disease. However, extracellular matrix (ECM) under stress model associated or not with diabetes remains unknown. This study aims to investigate the involvement of diabetes and unpredictable chronic mild stress (UCMS) on ECM remodelling. Rats were exposed to UCMS, diabetes or combined treatment. mRNA expression of matrix metalloproteinases (MMP-2 and MMP-9), plasminogen activator (t-PA) and inhibitor (PAI-1) was examined by Q-RT-PCR. ECM was determined by ELISA. MMP-2 and MMP-9 mRNA was lower in diabetes (P |
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Date |
2023-07-31T09:59:58Z
2023-07-31T09:59:58Z 2023-07 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62380 https://doi.org/ |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJEB Vol.61(08) [August 2023]
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