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Evaluation of anti-anxiety effects of the hydromethanolic extract of Boerhaavia diffusa L. roots in mice exposed to unpredictable chronic mild stress

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Title Evaluation of anti-anxiety effects of the hydromethanolic extract of
Boerhaavia diffusa L. roots in mice exposed to unpredictable chronic mild stress
 
Creator Kumari, Manisha
Sharma, Prasanti
Sharma, Neelima
 
Subject Antioxidant
Anxiolytic activity
Boerhaavia diffusa L
Phytochemical screening
Stress
 
Description 249-254
Stress and anxiety are common psychiatric manifestations seen because of modern-day living especially expressed
during demanding situations. Boerhaavia diffusa is an important medicinal plant widely used in the northeastern part of
India. This study aimed to investigate the antioxidant and anti-anxiety activities of the hydro-methanolic extract of B. diffusa
roots. The antioxidant property of the hydromethanolic extract of B.diffusa was determined by in vitro antioxidant assays
such as DPPH scavenging activity. The cytotoxicity of the extract was investigated using SH-SY5Y cell lines and the
anxiolytic activity was evaluated using the elevated plus maze test and open field tests. The results imply that the
hydromethanolic extract of B. diffusa showed excellent antioxidant activity. The extract did not show any significant
toxic effect on SH-SY5Y cells. The hydro-methanolic extract of B. diffusa also demonstrated significant anxiolytic activity
at 100 and 200 mg/kg doses. Thus, it can be concluded that the hydromethanolic extract of B. diffusa possesses anxiolytic
activity and antioxidant properties, proving its therapeutic usefulness in the treatment of anxiety disorders.
 
Date 2023-07-31T10:04:23Z
2023-07-31T10:04:23Z
2023-07
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62383
https://doi.org/10.56042/ijnpr.v14i2.4209
 
Language en
 
Relation A61K 36/00, A61K 125/00, A61P
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(2) [June 2023]