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Ganoderma applanatum (Pers.) Pat. augments antitumor activity of doxorubicin and provides chemoprevention to murine tumor model

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Title Ganoderma applanatum (Pers.) Pat. augments antitumor activity of doxorubicin and provides chemoprevention to murine tumor model
 
Creator Varghese, Ruby
Dalvi, Yogesh Bharat
Vijay, Namitha
Gowda, Vikram
 
Subject Artist's Fungus
Cancer
Cardioprotection
 
Description 606-613
Doxorubicin (DOX) is a chemotherapeutic drug, used widely in the treatment of a variety of solid and hematological
malignancies. However, its clinical utility is markedly reduced by dose-dependent cardiotoxicity. In the present study, Dalton
lymphoma Ascites (DLA) cell line was administered to create a solid tumor in a murine model. DOX (25 mg/kg body wt.) was
administered intraperitoneally in overnight fasted Swiss albino mice to induce cardiac toxicity and hepatotoxicity. Thirty
minutes before administering the chemotherapeutic drug, water-alcohol extract of the medicinal mushroom Ganoderma
applanatum (GAWE) was administered to allotted groups. After five days, the extent of heart damage was analyzed by
Electrocardiogram (ECG), further blood serum parameters, such as SGOT, SGPT, ALP, CK-MB, and LDH as well as
antioxidants, such as GSH, GPx and tissue peroxidation by MDA level was determined for both liver and heart tissues. The
mode of prevention by the mushroom extract from the damage caused by DOX at the molecular level and aberrations in tissue
morphology by histopathology was also analyzed. The increase in blood serum parameters and MDA levels were significantly
reduced with the GAWE administration. GAWE also upregulated heart and liver antioxidant enzymes and reduces ST, QT
interval, and QRS complex, and increased heart rate as compared to DOX treated group. GAWE dose-dependently mitigated
DOX-induced cellular discrepancies as evidenced by gene expression study and histological analysis. Hence, it can be
concluded that the water-alcohol extract of Ganoderma applanatum (GAWE), is a potent candidate for adjuvant chemotherapy
in cancer treatment as it effectively mitigated organ system drug-induced toxicities.
 
Date 2023-07-31T10:06:31Z
2023-07-31T10:06:31Z
2023-07
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/62385
https://doi.org/10.56042/ijeb.v61i08.3873
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJEB Vol.61(08) [August 2023]