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Enhanced efficacy of 5-fluorouracil combined with chrysin in treating colorectal cancer in BALB/c mice: Impact on β-catenin and inducible nitric oxide synthase expression

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Title Enhanced efficacy of 5-fluorouracil combined with chrysin in treating colorectal cancer in BALB/c mice: Impact on β-catenin and inducible nitric oxide synthase expression
 
Creator Alipour, Marzieh
Yosefi, Sedighe
Pakdel, Abbas
Sameni, Hamid Reza
Semnani, Vahid
Bandegi, Ahmad Reza
 
Subject Azoxymethane
Catenins
Chrysin
Colorectal neoplasms
Fluorouracil
Nitric oxide synthase type II
 
Description 229-236
Chrysin is a naturally occurring bioflavonoid found in honey and propolis, with anti-cancer and anti-inflammatory
properties. This study aimed to investigate the therapeutic effect of chrysin combined with 5-fluorouracil (5-FU) in the
treatment of mice with colorectal cancer (CRC). Moreover, the effects of these two compounds on the expression of
β-catenin and inducible nitric oxide synthase (iNOS) were investigated. The CRC was induced in the mice by azoxymethane
(AOM). The co-administration of 5-FU and chrysin in the treatment of mice reduced the number of aberrant crypt foci
(ACF) and the pathologic lesion percentage compared to other treatment groups (P
 
Date 2023-07-31T10:09:56Z
2023-07-31T10:09:56Z
2023-07
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62388
https://doi.org/10.56042/ijnpr.v14i2.4207
 
Language en
 
Relation A61K 36/00, A61P 35/00
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(2) [June 2023]