Enhanced efficacy of 5-fluorouracil combined with chrysin in treating colorectal cancer in BALB/c mice: Impact on β-catenin and inducible nitric oxide synthase expression
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Title |
Enhanced efficacy of 5-fluorouracil combined with chrysin in treating colorectal cancer in BALB/c mice: Impact on β-catenin and inducible nitric oxide synthase expression
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Creator |
Alipour, Marzieh
Yosefi, Sedighe Pakdel, Abbas Sameni, Hamid Reza Semnani, Vahid Bandegi, Ahmad Reza |
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Subject |
Azoxymethane
Catenins Chrysin Colorectal neoplasms Fluorouracil Nitric oxide synthase type II |
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Description |
229-236
Chrysin is a naturally occurring bioflavonoid found in honey and propolis, with anti-cancer and anti-inflammatory properties. This study aimed to investigate the therapeutic effect of chrysin combined with 5-fluorouracil (5-FU) in the treatment of mice with colorectal cancer (CRC). Moreover, the effects of these two compounds on the expression of β-catenin and inducible nitric oxide synthase (iNOS) were investigated. The CRC was induced in the mice by azoxymethane (AOM). The co-administration of 5-FU and chrysin in the treatment of mice reduced the number of aberrant crypt foci (ACF) and the pathologic lesion percentage compared to other treatment groups (P |
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Date |
2023-07-31T10:09:56Z
2023-07-31T10:09:56Z 2023-07 |
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Type |
Article
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Identifier |
0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62388 https://doi.org/10.56042/ijnpr.v14i2.4207 |
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Language |
en
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Relation |
A61K 36/00, A61P 35/00
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Publisher |
NIScPR-CSIR, India
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Source |
IJNPR Vol.14(2) [June 2023]
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