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Food spices as potential therapeutic agents in targeting inflammatory cytokine storm: A review on underlying mechanisms and therapeutic targeting strategies for SARS-CoV2

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Field Value
 
Title Food spices as potential therapeutic agents in targeting inflammatory cytokine storm: A review on underlying mechanisms and therapeutic targeting strategies for SARS-CoV2
 
Creator Rathod, Priyanka
Yadav, Raman P
 
Subject COVID19
Cytokine storm
Natural products
SARS-CoV2
Spices
Structural targets
 
Description 185-201
Since ancient times, spices such as black pepper, cinnamon, ginger, turmeric, garlic, black cumin, clove, ocimum,
saffron, and nutmeg constitute an important part of foods and beverages in India. Besides, adding aroma and flavour to the
food, they are also known for multiple medicinal benefits. During the COVID-19 pandemic, an interesting pattern of disease
prevalence and severity was observed especially in the countries where spices are consumed regularly. It has attracted
researchers worldwide to explore the therapeutic potential of spices in COVID-19 management. Various in silico studies
have reported good binding affinities of spices and derived components towards structural druggable targets of SARSCoV2.
There are several compelling pieces of evidence for the role of spices in the attenuation of inflammatory cytokine
storm which is the crux in the pathogenesis of COVID-19. Therefore, this review is written to provide deep insights into the
role of food spices and their underlying mechanism in targeting SARS-CoV2. Based on experimentally verified data from
different in-vitro, in-vivo, in-silico, and clinical studies, the information presented will certainly help in the development of
promising drug therapeutics or preventive strategies to deal with SARS-CoV2. Further studies geared towards the
development of drugs based on spices and derived compounds are suggested.
 
Date 2023-07-31T10:25:15Z
2023-07-31T10:25:15Z
2023-07
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/62392
https://doi.org/10.56042/ijnpr.v14i2.4204
 
Language en
 
Relation A61K 36/00, A61P
 
Publisher NIScPR-CSIR, India
 
Source IJNPR Vol.14(2) [June 2023]