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A microscopy study to distinguish the ultrastructural changes in the ciliated epithelium, type II pneumocytes, macrophages, and neutrophils of bronchoalveolar fluids after severe SARS-CoV-2 infection

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Title A microscopy study to distinguish the ultrastructural changes in the ciliated epithelium, type II pneumocytes, macrophages, and neutrophils of bronchoalveolar fluids after severe SARS-CoV-2 infection
 
Creator Chaudhary, Shikha
Yadav, Ravi Prakash
Yadav, Subhash Chandra
 
Subject Bronchoalveolar fluids
Ciliated epithelium
Macrophages
Neutrophils
SARS-CoV-2
Type II pneumocytes
 
Description 545-554
SARS-CoV-2 infection has an adverse effect on the functioning of various respiratory and hematopoietic cells in the
bronchoalveolar fluid (BALF) resulting from ultrastructural alterations. These ultrastructural changes were directly
corroborated to understand the altered function of these cells. These changes have been sparingly reported and it is
important for understanding the biology of COVID-19. We have reported various ultrastructural alterations of ciliated
epithelium, type II pneumocytes, macrophages, and neutrophils individually from the BALF of patients with severe
COVID-19. Ultrastructural alterations depend on various conditions such as age, immunity, associated comorbidities,
disease severity, and medication received by patients. The ciliated epithelium mostly contained viral-containing
compartments, horseshoe-shaped mitochondria, necrosis, and double-membrane vesicles. Type II pneumocyte cells showed
cytoplasmic vacuolization, loss of lamellar bodies, and the formation of viral inclusion bodies. The alveolar macrophages
displayed increased size and number of phagocytic vacuoles containing viral particles (phagosomes) and vacuolated
cytoplasm. Neutrophils showed cytoplasmic granularity, vacuolization, and the presence of extracellular traps. This study
provides important insights into the cellular and morphological changes associated with COVID-19 in BALF cells.
 
Date 2023-08-03T07:10:51Z
2023-08-03T07:10:51Z
2023-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62400
https://doi.org/10.56042/ijbb.v60i7.4371
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(07) [July 2023]