Aplastic anemia patients with severe COVID-19 showed abnormal ultrastructure features on type II pneumocytes of lungs
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Title |
Aplastic anemia patients with severe COVID-19 showed abnormal ultrastructure features on type II pneumocytes of lungs
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Creator |
Chaudhary, Shikha
Yadav, Ravi P Kumar, Shailendra Yadav, Subhash C |
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Subject |
Pancytopenia
Surfactant granules Type II pneumocytes |
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Description |
589-595
Type-II-pneumocytes from the bronchoalveolar fluids of aplastic anemia (AA) patients with COVID-19-induced acute respiratory distress syndrome (ARDS) were imaged to assess the ultrastructural alteration, especially in the number and size of the lamellar bodies. The mild (non-ARDS), and severe ARDS without comorbidities were used as reference for comparative ultrastructural analysis. The electron microscopic imaging of mild non-ARDS patients showed normal ultrastructure with surfactant-containing lamellar bodies of size range 0.5-1.00 μM with an area ranging from 0.3-0.8 μM2. The ARDS patients with diabetes and without any comorbidities showed larger lamellar bodies of the size range 0.8-1.4 μM with an area range from 0.5-1.50 μM2. However, AA patients revealed normal and giant lamellar bodies. These giant lamellar bodies showed a size range of 2.0-4.0 μM with an area ranging from 3.0- 5.0 μM2 with a lesser number/cell. This study reports the abnormal ultrastructural alteration of type II pneumocytes in AA patients with COVID-19. |
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Date |
2023-08-14T09:41:13Z
2023-08-14T09:41:13Z 2023-08 |
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Type |
Article
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Identifier |
0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62421 https://doi.org/10.56042/ijbb.v60i8.4293 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJBB Vol.60(08) [August 2023]
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