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Aplastic anemia patients with severe COVID-19 showed abnormal ultrastructure features on type II pneumocytes of lungs

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Title Aplastic anemia patients with severe COVID-19 showed abnormal ultrastructure features on type II pneumocytes of lungs
 
Creator Chaudhary, Shikha
Yadav, Ravi P
Kumar, Shailendra
Yadav, Subhash C
 
Subject Pancytopenia
Surfactant granules
Type II pneumocytes
 
Description 589-595
Type-II-pneumocytes from the bronchoalveolar fluids of aplastic anemia (AA) patients with COVID-19-induced acute
respiratory distress syndrome (ARDS) were imaged to assess the ultrastructural alteration, especially in the number and size of
the lamellar bodies. The mild (non-ARDS), and severe ARDS without comorbidities were used as reference for comparative
ultrastructural analysis. The electron microscopic imaging of mild non-ARDS patients showed normal ultrastructure with
surfactant-containing lamellar bodies of size range 0.5-1.00 μM with an area ranging from 0.3-0.8 μM2. The ARDS patients
with diabetes and without any comorbidities showed larger lamellar bodies of the size range 0.8-1.4 μM with an area range
from 0.5-1.50 μM2. However, AA patients revealed normal and giant lamellar bodies. These giant lamellar bodies showed a
size range of 2.0-4.0 μM with an area ranging from 3.0- 5.0 μM2 with a lesser number/cell. This study reports the abnormal
ultrastructural alteration of type II pneumocytes in AA patients with COVID-19.
 
Date 2023-08-14T09:41:13Z
2023-08-14T09:41:13Z
2023-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/62421
https://doi.org/10.56042/ijbb.v60i8.4293
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.60(08) [August 2023]