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Design and synthesis of new tricyclic quinoline derivatives from intramolecular cyclization of benzylidene malonic derivatives

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Title Design and synthesis of new tricyclic quinoline derivatives from intramolecular cyclization of benzylidene malonic derivatives
 
Creator Timotou, Adéyolé
Camara, Tchambaga Etienne
Molou, Kouassi Yves Guillaume
Coulibaly, Souleymane
Zon, Doumadé
Kablan, Ahmont Landry Claude
N’Gouan, Aka Joseph
Coulibali, Siomenan
Adjou, Ané
 
Subject Tricyclic quinoline
Malonic benzylidene
Intramolecular cyclization
Malononitrile
Ethyl cyanoacetate
X-ray crystallography
 
Description 879-883
Quinolines are very important compounds due to their numerous biological and pharmacological applications. This
article describes the synthesis of new tricyclic quinoline derivatives via intramolecular cyclization of malonic benzylidene
derivatives. The malonic benzylidene derivatives 2a-c have been obtained by condensation of N-substituted aldehydes 1a-c
with malononitrile or ethyl cyanoacetate. These latter have been cyclized by reflux in DMF to give the compounds 3a-f. The
structures of the compounds have been determined by 1
H and 13C NMR spectroscopy, and High-Resolution Mass
Spectrometry (HRMS) analysis. Two of the synthesized compounds have been identified and confirmed by X-ray
crystallography.
 
Date 2023-08-16T11:23:15Z
2023-08-16T11:23:15Z
2023-08
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62429
https://doi.org/10.56042/ijc.v62i8.4795
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(08) [August 2023]