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Convergent and efficient synthesis of 1,2,4-triazolo[5,1-b]quinazolin-8-ones using copper incorporated hydroxyapatite encapsulated Kit-6 as a recoverable nanocatalyst

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Title Convergent and efficient synthesis of 1,2,4-triazolo[5,1-b]quinazolin-8-ones using copper incorporated hydroxyapatite encapsulated Kit-6 as a recoverable nanocatalyst
 
Creator Pirdelzendeh, Dornaz
Mamaghani, Manouchehr
Shirini, Farhad
Sheykhan, Mehdi
 
Subject Nanocatalyst
quinazoline
hydroxyapatite
dimedone
3-amino-1,2,4-triazole
 
Description 856-865
Copper incorporated hydroxyapatite encapsulated Kit-6 (Cu@HAp@KIT-6) has been used as an effective nanocatalyst
in the synthesis of 1,2,4-triazolo[5,1-b]quinazolin-8-one derivatives by a one-pot reaction of 3-amino-1,2,4-triazole,
dimedone and aromatic aldehydes in ethanol. This novel protocol affords the products under optimized reaction conditions
with high to excellent yields (88-97%) and lower reaction times (40-50 min). Wide substrate scope, facile work-up
procedure, reduced reaction time, the use of green solvent and recyclability of the catalyst are some prominent advantages of
this protocol. The catalytic activity of the catalyst after six consecutive runs has been preserved without an appreciable
decrease in its activity.
 
Date 2023-08-16T12:31:37Z
2023-08-16T12:31:37Z
2023-08
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62451
https://doi.org/10.56042/ijc.v62i8.4776
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(08) [August 2023]