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Design, synthesis and in vitro antimicrobial activity of furan-based pyrimidinethiazolidinones as potential bioactive molecules

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Title Design, synthesis and in vitro antimicrobial activity of furan-based pyrimidinethiazolidinones as potential bioactive molecules
 
Creator Desai, Nisheeth C
Jethawa, Aratiba M
Monapara, Jahnvi
 
Subject Antimicrobial activity
Furan
Thiazolidinone
Pyrimidine
 
Description 827-833
Antimicrobial resistance (AMR) to currently available drugs is a major source of worry for researchers. Antibiotic
treatment is insufficient and ineffective against many bacteria and fungi as a result of antimicrobial resistance. Novel
antimicrobial drugs that can successfully combat microbial resistance are urgently needed. In order to assess their
antimicrobial activity, furan-based thiazolidinone and pyrimidine scaffolds (8a–o) have been developed and synthesized. IR,
1H and 13C NMR, and mass spectrometry have been used to characterize the structures of the newly synthesized analogues
(8a–o). The synthesized compounds have been tested for their antimicrobial properties against diverse bacterial and fungal
strains. At MIC 12.5 μg/mL, compound 8k shows efficacy against E. coli. Compounds 8d and 8e demonstrate antifungal
activity against A. niger at 100 μg/mL. Chloramphenicol, ciprofloxacin and griseofulvin have been employed as reference
drugs.
 
Date 2023-08-16T12:48:20Z
2023-08-16T12:48:20Z
2023-08
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/62455
https://doi.org/10.56042/ijc.v62i8.1175
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(08) [August 2023]