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Neutralization of enterotoxins of Escherichia coli by coleonol (Forskolin) in rabbit and guineapig ileal loop models

Indian Agricultural Research Journals

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Title Neutralization of enterotoxins of Escherichia coli by coleonol (Forskolin) in rabbit and guineapig ileal loop models
 
Creator YADAVA, J N S
GUPTA, SHASHI
AHMAD, IQBAL
VERMA, NEERAJ
TANDON, J S
 
Subject —
 
Description A crude alcoholic extract of Coleus froskohlii Briq. roots showed marked inhibitory action against Eschrichia colt toxin induced secretary response at 300 mg/100 p dose in rabbits and guncapig ileal loops. Coleonol A and B obtained by column chromatography of a henzene fraction of the aicoholic extract of Coteus froskushlu roots exhibited antisecrery (antidiarrhocal)activity at 1 mg does/loop. Coleonol-A showed nearly 79% inhibition against heat labilc LT) toxin and 67% against heat stable (ST) toxin induced secretions However, coleonol-B exhited less activity against ST (68.3%) enteroloxins as compared to the widely used antidiarrhoeal (antisecrotory) drug. Loperamide (an opiate aganist) which showed 77 and 65% inhibution against LT and ST toxins, respectively, at a similar does.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2013-10-14
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/33883
 
Source The Indian Journal of Animal Sciences; Vol 65, No 11 (1995)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/33883/15029
 
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