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Disposition kinetics of gentamicin following intramuscular (IM) administration in kidney damaged goats

Indian Agricultural Research Journals

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Title Disposition kinetics of gentamicin following intramuscular (IM) administration in kidney damaged goats
 
Creator Ahmad, A H
Sharma, L D
 
Subject Disposition kinetics; Gentamicin; Renal-impaired goats
 
Description Disposition kinetics of gentamicin following single dose (5 mg/kg bw) intramuscular (IM) administration in kidney damaged (renal-impaired )goats was investigated. Kidney in goats was damaged by injecting single IV dose (5 mg/kg bw) of uranyl nitrate. The extent of damage was measured as serum creatinine and blood urea nitrogen levels. A one- compartment model adequately described the plasma concentration time profile, The absorption of gentamicin, following IM administration was rapid, with peak plasma concentration achieved within 30-60 min in renal-impaired goats. Therapeutic concentration (5µg/ml) was maintained up to 18hr. An elimination half·life of 482min was observed. Volume of distribution (Vd/F) was 198.4 ml/kg. Clearance value was 0.26 ml/kg/min. Based on the pharmacokinetic data, dosage regimen in renal-impaired goats was calculated.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2012-07-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/22423
 
Source The Indian Journal of Animal Sciences; Vol 68, No 11 (1998)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/22423/11016
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences